Chair of Preclinical Science, Department of Medical Informatics and Statistics with e-Health Lab, Medical University of Lublin, K. Jaczewskiego 5 Street, 20-059, Lublin, Poland.
Specialistic Medical Center Czechow, Lublin, Poland.
Sci Rep. 2024 Oct 22;14(1):24884. doi: 10.1038/s41598-024-76896-8.
Endometrial cancer is one of the most common gynaecological cancers in the developed countries. The aim of this study was to determine the impact of hypertension on endometrial cancer risk. Databases: PubMed, Embase and the Cochrane Library were searched from January 2000 to June 2024. We used DerSimonian-Laird random-effects model for analysis. Risk estimates were extracted by two authors and summarized using meta-analytic methods. A total of 26 observational studies with 207,502 endometrial cancer cases were included in the study. Overall meta-analysis demonstrates significant association between hypertension and endometrial cancer risk (RR = 1.37, 95% CI: 1.27-1.47, p < 0.001). Subgroup analysis of the risk of endometrial cancer shows statistically significant higher risk in patients with BMI ≥ 30 kg/m2, diabetics, women who had their first menstrual period at the age of 11 years or earlier, and who had never given birth. Findings of this comprehensive review and meta-analysis indicate that hypertension is associated with higher overall risk of endometrial cancer.
子宫内膜癌是发达国家最常见的妇科癌症之一。本研究旨在确定高血压对子宫内膜癌风险的影响。数据库：从 2000 年 1 月至 2024 年 6 月，我们检索了 PubMed、Embase 和 Cochrane Library。我们使用 DerSimonian-Laird 随机效应模型进行分析。两位作者提取风险估计值，并使用荟萃分析方法进行总结。共有 26 项观察性研究纳入了 207502 例子宫内膜癌病例。总体荟萃分析表明高血压与子宫内膜癌风险之间存在显著关联（RR=1.37，95%CI：1.27-1.47，p<0.001）。子宫内膜癌风险的亚组分析显示，BMI≥30kg/m2、糖尿病、初潮年龄为 11 岁或更早、从未生育的患者的风险显著更高。本综述和荟萃分析的结果表明，高血压与子宫内膜癌的总体风险增加相关。
