Department of Obstetrics and Gynecology, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University, Beijing, China.
Front Endocrinol (Lausanne). 2024 Aug 27;15:1409469. doi: 10.3389/fendo.2024.1409469. eCollection 2024.
Endometriosis is delineated as a benign yet steroid-dependent disorder characterized by the ectopic presence of endometrial glandular and stromal cells outside the uterine cavity, affecting estimated 10%-15% of women of reproductive age, 20%-50% of all women with infertility and costing a great economic burden per-patient. Endometriosis exerts pervasive influence on multiple facets of female reproductive physiology. Given its characterization as a chronic inflammatory disorder, escalated levels of pro-inflammatory cytokines were unequivocally recognized as well-established characteristics of endometriosis, which might attribute to mechanisms like retrograde menstruation, progesterone receptor resistance, and immune dysregulation. Therapeutic utilization of non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, analgesic agent for reducing pain, inflammation, and fever, could be holding promise in augmenting reproductive outcomes of endometriosis women. Therefore, the objective of this comprehensive review is to elucidate the intricate interplay between endometriosis and aspirin, both within the context of infertility and beyond. We meticulously explore potential pharmacological agents targeting endometriosis, which may concurrently optimize the efficacy of reproductive interventions, while also delving into the underlying mechanistic pathways linking endometriosis with inflammatory processes.
We conducted a comprehensive search in the data available in and the using the terms 'endometriosis' and 'aspirin'. Then analyzed the identified articles based on established inclusion and exclusion criteria independently by three reviewers.
The survey of the chosen terms revealed 72 articles, only 10 of which were considered for review.
Based on the research available currently, it is not substantial enough to address the conclusion that aspirin shall be an effective therapeutic choice for endometriosis, further studies are needed to elucidate the efficacy, safety profile, and optimal dosing regimens of aspirin in the context of endometriosis treatment.
子宫内膜异位症是一种良性但依赖于甾体的疾病，其特征是子宫内膜腺和基质细胞在子宫腔外异位存在，影响估计有 10%-15%的育龄妇女，20%-50%的所有不孕妇女，并给每位患者带来巨大的经济负担。子宫内膜异位症对女性生殖生理的多个方面都有广泛的影响。鉴于其作为一种慢性炎症性疾病的特征，升高的促炎细胞因子水平被明确认为是子宫内膜异位症的既定特征，这可能归因于逆行性月经、孕激素受体抵抗和免疫失调等机制。非甾体抗炎药（NSAIDs）如阿司匹林的治疗应用，作为一种止痛剂，可减轻疼痛、炎症和发热，可能在增强子宫内膜异位症妇女的生殖结局方面有一定的前景。因此，本综述的目的是阐明子宫内膜异位症和阿司匹林之间的复杂相互作用，包括在不孕和其他方面。我们细致地探讨了针对子宫内膜异位症的潜在药物治疗，这可能同时优化生殖干预的效果，同时深入研究将子宫内膜异位症与炎症过程联系起来的潜在机制途径。
我们在 和 中使用“子宫内膜异位症”和“阿司匹林”这两个术语进行了全面搜索。然后，由三位评审员独立根据既定的纳入和排除标准对已确定的文章进行分析。
对所选术语的调查显示有 72 篇文章，其中只有 10 篇被认为适合审查。
根据目前可获得的研究，阿司匹林作为子宫内膜异位症的有效治疗选择的结论还不够充分，需要进一步研究来阐明阿司匹林在子宫内膜异位症治疗中的疗效、安全性概况和最佳剂量方案。
