Zhang Zhuodan, Xia Yi, Li Xinyi, Zhang Qian, Wu Yuanhao, Cui Chunyan, Liu Jianfeng, Liu Wenguang
School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300352, China.
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Bioact Mater. 2024 Aug 23;40:667-682. doi: 10.1016/j.bioactmat.2024.08.014. eCollection 2024 Oct.
Breast cancer is the most common cancer among women worldwide, and adjuvant radiotherapy (RT) following tumor removal is one of the most commonly used treatments for breast cancer. However, the high risk of tumor recurrence and inevitable radiation skin injury after RT remain fatal problems, seriously challenging the patient's postoperative rehabilitation. Herein, a multifunctional poly (lipoic acid)-based hydrogel is constructed through one-step heating the mixture of α-lipoic acid (LA)/arginine (Arg)/silk fibroin (SF), without introducing any non-natural molecules. The multiple synergistic interactions among LA, Arg, and SF not only enhance the solubilization of LA in aqueous systems but also stabilize poly(lipoic acid) through strong salt bridge hydrogen bonds and ionic hydrogen bonds. Intriguingly, the LA-based surfactant induced β-sheet transformation of SF can further modulate the bulk strength of the hydrogel. Regulating the content of LA in hydrogels not only allows efficient control of hydrogel bioactivity but also enables the evolution of hydrogels from injectable forms to adhesive patches. Based on the different biological activities and forms of hydrogels, they can be implanted internally or applied externally on the mice's skin, achieving simultaneous prevention of tumor recurrence post-surgery and assistance in treating radiation-induced skin damage after radiotherapy.
乳腺癌是全球女性中最常见的癌症，肿瘤切除后的辅助放疗（RT）是乳腺癌最常用的治疗方法之一。然而，放疗后肿瘤复发的高风险和不可避免的放射性皮肤损伤仍然是致命问题，严重挑战患者的术后康复。在此，通过一步加热α-硫辛酸（LA）/精氨酸（Arg）/丝素蛋白（SF）的混合物构建了一种多功能聚（硫辛酸）基水凝胶，无需引入任何非天然分子。LA、Arg和SF之间的多重协同相互作用不仅增强了LA在水性体系中的溶解性，还通过强盐桥氢键和离子氢键稳定了聚（硫辛酸）。有趣的是，基于LA的表面活性剂诱导的SF的β-折叠转变可进一步调节水凝胶的整体强度。调节水凝胶中LA的含量不仅可以有效控制水凝胶的生物活性，还能使水凝胶从可注射形式演变为贴片。基于水凝胶不同的生物活性和形式，它们可以在小鼠体内植入或在皮肤外部应用，实现术后同时预防肿瘤复发和辅助治疗放疗后放射性皮肤损伤。
