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一种可注射、自愈合、具有粘性的多功能水凝胶促进细菌感染伤口愈合。

An Injectable, Self-Healing, Adhesive Multifunctional Hydrogel Promotes Bacteria-Infected Wound Healing.

作者信息

Zhang Ling, Wang Yan, Yang Mingrui, Yu Wen, Zhao Zheng, Liu Yichao

机构信息

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

Hospital of Wuhan University of Technology, Wuhan 430070, China.

出版信息

Polymers (Basel). 2024 May 8;16(10):1316. doi: 10.3390/polym16101316.

DOI:10.3390/polym16101316
PMID:38794508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11124967/
Abstract

Bacterial infections have a serious impact on public health. It is urgent to develop antibacterial hydrogels with good biocompatibility to reduce the use of antibiotics. In this study, poly(lipoic acid-co-sodium lipoate)-phytic acid (P(LA-SL)-PA) hydrogels are prepared by a simple mixture of the natural small molecules lipoic acid (LA) and phytic acid (PA) in a mild and green reaction environment. The crosslinking network is constructed through the connection of covalent disulfide bonds as well as the hydrogen bonds, which endow the injectable and self-healing properties. The P(LA-SL)-PA hydrogels exhibit an adjustable compression modulus and adhesion. The in vitro agar plates assay indicates that the antibacterial rate of hydrogels against and is close to 95%. In the rat-infected wound model, the P(LA-SL)-PA hydrogels adhere closely to the tissue and promote epithelialization and collagen deposition with a significant effect on wound healing. These results prove that the P(LA-SL)-PA hydrogels could act as effective wound dressings for promoting the healing of infected wounds.

摘要

细菌感染对公众健康有严重影响。开发具有良好生物相容性的抗菌水凝胶以减少抗生素的使用迫在眉睫。在本研究中，聚（硫辛酸 - 硫代硫酸钠） - 植酸（P(LA - SL)-PA）水凝胶是通过在温和且绿色的反应环境中，将天然小分子硫辛酸（LA）和植酸（PA）简单混合制备而成。交联网络通过共价二硫键以及氢键的连接构建而成，赋予了其可注射性和自愈性能。P(LA - SL)-PA水凝胶表现出可调节的压缩模量和粘附性。体外琼脂平板试验表明，水凝胶对[具体细菌名称1]和[具体细菌名称2]的抗菌率接近95%。在大鼠感染伤口模型中，P(LA - SL)-PA水凝胶紧密粘附于组织，促进上皮化和胶原蛋白沉积，对伤口愈合有显著效果。这些结果证明，P(LA - SL)-PA水凝胶可作为促进感染伤口愈合的有效伤口敷料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/1ce18873ac54/polymers-16-01316-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/ff4d6260795f/polymers-16-01316-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/8f727814348e/polymers-16-01316-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/2983049b6d2c/polymers-16-01316-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/6e4ebda50777/polymers-16-01316-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/af7d346911be/polymers-16-01316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/f01435a525a0/polymers-16-01316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/9676d721a7db/polymers-16-01316-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/3c1c82d0a7ab/polymers-16-01316-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/6ee759148b43/polymers-16-01316-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/52ed6be72f46/polymers-16-01316-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/1ce18873ac54/polymers-16-01316-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/ff4d6260795f/polymers-16-01316-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/8f727814348e/polymers-16-01316-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/2983049b6d2c/polymers-16-01316-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/6e4ebda50777/polymers-16-01316-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/af7d346911be/polymers-16-01316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/f01435a525a0/polymers-16-01316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/9676d721a7db/polymers-16-01316-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/3c1c82d0a7ab/polymers-16-01316-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/6ee759148b43/polymers-16-01316-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/52ed6be72f46/polymers-16-01316-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce4f/11124967/1ce18873ac54/polymers-16-01316-g007.jpg

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[2]
A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer.

Nat Commun. 2023-11-24

[3]
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[4]
Injectable hydrogel based on silk fibroin/carboxymethyl cellulose/agarose containing polydopamine functionalized graphene oxide with conductivity, hemostasis, antibacterial, and anti-oxidant properties for full-thickness burn healing.

Int J Biol Macromol. 2023-9-30

[5]
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[6]
Self-healing, self-adhesive, and stretchable conductive hydrogel for multifunctional sensor prepared by catechol modified nanocellulose stabilized poly(α-thioctic acid).

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[7]
Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair.

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[8]
Injectable, self-healable and antibacterial multi-responsive tunicate cellulose nanocrystals strengthened supramolecular hydrogels for wound dressings.

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[9]
Green polymer hydrogels from a natural monomer with inherent antioxidative capability for efficient wound healing and spinal cord injury treatment.

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[10]
Facile fabrication of self-healing, injectable and antimicrobial cationic guar gum hydrogel dressings driven by hydrogen bonds.

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