富氢水对高尿酸血症患者血尿酸的影响：一项随机安慰剂对照试验。
Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial.
作者信息
Wu Fenglin, Ma Jun, Xue Junli, Jiang Xue, Liu Jinyu, Zhang Jiashuo, Xue Yazhuo, Liu Boyan, Qin Shucun
机构信息
Shandong Provincial Key Medical and Health Laboratory of Hydrogen Biomedical Research & Key Laboratory of Major Diseases and Hydrogen Medical Translational Applications in Universities of Shandong Province, Taishan Institute for Hydrogen Biomedical Research, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
College of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China.
出版信息
Heliyon. 2024 Aug 15;10(16):e36401. doi: 10.1016/j.heliyon.2024.e36401. eCollection 2024 Aug 30.
BACKGROUND
Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits.
OBJECTIVE
A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
METHODS
The Placebo group consumed three bottles of ordinary drinking water (330 mL per bottle), the Low-HRW group consumed two bottles of HRW (330 mL per bottle, H ≥ 4.66 mg/L) and a bottle of ordinary water, and the High-HRW group consumed three bottles of HRW daily for 8 weeks. The primary outcome was the blood uric acid levels following different time points (4 and 8 weeks) compared to baseline.
RESULTS
A total of 100 participants completed the entire trial (32 in Placebo, 35 in Low-HRW, and 33 in High-HRW groups). The high-dose of HRW was more effective than low-dose HRW in controlling blood uric acid. Following an 8-week period, the High-HRW group exhibited a significant reduction in blood uric acid levels compared to the baseline (488.2 ± 54.1 μmol/L to 446.8 ± 57.1 μmol/L, < 0.05).
CONCLUSION
As a rather safe agent, the prolonged consumption of HRW may be feasible in the management of hyperuricemia.
CLINICAL TRIAL REGISTRATION
chictr.org.cn, identifier ChiCTR2200066369.
背景
饮用富氢水（HRW）已被证明具有抗炎和代谢调节作用。
目的
进行一项随机、安慰剂对照试验，以评估不同剂量（低剂量和高剂量）和持续时间（4周和8周）饮用HRW对高尿酸血症患者血尿酸的潜在降低作用。
方法
安慰剂组饮用三瓶普通饮用水（每瓶330毫升），低剂量HRW组饮用两瓶HRW（每瓶330毫升，氢含量≥4.66毫克/升）和一瓶普通水，高剂量HRW组每天饮用三瓶HRW，持续8周。主要观察指标是与基线相比，不同时间点（4周和8周）后的血尿酸水平。
结果
共有100名参与者完成了整个试验（安慰剂组32人，低剂量HRW组35人，高剂量HRW组33人）。高剂量HRW在控制血尿酸方面比低剂量HRW更有效。8周后，高剂量HRW组的血尿酸水平与基线相比显著降低（从488.2±54.1微摩尔/升降至446.8±57.1微摩尔/升，P<0.05）。
结论
作为一种相当安全的药物，长期饮用HRW可能是治疗高尿酸血症的可行方法。
临床试验注册
chictr.org.cn，标识符ChiCTR2200066369。
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