使用免疫性不育男性的精子细胞成功进行体外受精。

Successful in vitro fertilization with sperm cells from a man with immune infertility.

作者信息

Naaktgeboren N, Devroey P, van Steirteghem A C

出版信息

Ann N Y Acad Sci. 1985;442:304-9. doi: 10.1111/j.1749-6632.1985.tb37533.x.

DOI:10.1111/j.1749-6632.1985.tb37533.x

Abstract

In vitro fertilization and embryo transfer was carried out in a couple that has been infertile for 7 years. High titers of antisperm autoantibodies in the husband's serum are (table, see text) believed to be the main cause of their infertility. Prolonged methylprednisolone treatment of the man combined with artificial insemination remained unsuccessful. In two IVF attempts embryos were obtained and replaced using capacitated sperm of the husband. A pregnancy was established in the second IVF cycle, but a spontaneous abortion followed after 6 weeks of amenorrhea.

摘要

对一对已不孕7年的夫妇进行了体外受精和胚胎移植。丈夫血清中抗精子自身抗体的高滴度（见表，见正文）被认为是他们不孕的主要原因。对该男子进行长时间的甲泼尼龙治疗并结合人工授精均未成功。在两次体外受精尝试中，获得了胚胎并使用丈夫的获能精子进行了移植。在第二个体外受精周期中成功妊娠，但闭经6周后发生了自然流产。