Yonemura Y, Hashimoto T, Miyata R, Takegawa S, Kamata T, Katayama K, Sawa T, Miyazaki I, Saito Y, Nakajima K
Gan To Kagaku Ryoho. 1985 Jul;12(7):1491-5.
A 56-year-old woman was diagnosed as having gastric cancer with lymph node metastasis and invasion to the pancreas head and was admitted to our hospital in September, 1984. She was treated with hyperthermo-chemo-radiotherapy, using radiofrequency-induced hyperthermia (8 MHz) with a daily dose of fractionations at 42-43 degrees C for 60 minutes, 5 fractions per week of irradiation at 180 cGy and systemic chemotherapy. After the total doses of hyperthermia and radiation had reached 11.8 hours and 2500 cGy, the primary tumor and lymph node metastasis measured by X-ray examination were reduced in size. On October 8th, laparotomy was done, and total gastrectomy combined with total pancreatectomy, left hepatic lobectomy and right hemicolectomy was performed. Histologically, almost all of the cancer cells in the primary tumor and lymph node metastasis had disappeared. These results show that this multimodal therapy is effective for local control of gastric cancer, when used preoperatively.
一名56岁女性被诊断为患有伴有淋巴结转移及侵犯胰头的胃癌，并于1984年9月入住我院。她接受了热化疗放疗，采用射频诱导热疗（8兆赫），每日分次剂量在42 - 43摄氏度持续60分钟，每周5次分次照射，每次180厘戈瑞，并进行全身化疗。在热疗和放疗的总剂量分别达到11.8小时和2500厘戈瑞后，经X线检查测量，原发肿瘤和淋巴结转移灶体积缩小。10月8日进行了剖腹手术，施行全胃切除术联合全胰切除术、左肝叶切除术及右半结肠切除术。组织学检查显示，原发肿瘤和淋巴结转移灶中的几乎所有癌细胞均已消失。这些结果表明，这种多模式疗法术前用于胃癌的局部控制是有效的。
