Bektaş Fatma Merve, Tekeli Oya
Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey.
J Glaucoma. 2025 Feb 1;34(2):95-102. doi: 10.1097/IJG.0000000000002495. Epub 2024 Sep 12.
In addition to standard automated perimetry tests, contrast sensitivity (CS) testing and macular analyses may predict changes in the quality of life (QOL) in patients at different stages of glaucoma.
To examine the relationship between functional and structural tests of visual function and the 25-item National Eye Institute-Visual Function Questionnaire (NEI-VFQ-25) and the 36-item Short Form (SF-36) Health Survey in patients with different stages of glaucoma.
Standard automated perimetry tests, optical coherence tomography scans, and CS testing were prospectively performed in 160 patients with glaucoma. The Hoddap-Parrish-Anderson staging system was used for glaucoma staging. Health-related QOL questionnaires (NEI-VFQ-25, SF-36) were also administered to all patients.
The study group comprised 29 patients with suspected glaucoma, 104 with mild glaucoma, 15 with moderate glaucoma, and 12 with severe glaucoma. The mean total score of the NEI-VFQ-25 was 88.8 ± 8.2. The SF-36 did not show a significant correlation with the data on functional and structural tests of visual function, whereas the NEI-VFQ-25 showed a low to moderate correlation ( r = 0.212 to -0.492). Vision parameters can explain up to 18.6% of the total score of the NEI-VFQ-25. CS was the only function significantly correlated with glaucoma suspects, whereas, in the early stages, visual acuity was the strongest correlated function with the NEI-VFQ-25 total score ( P = 0.003 and r = 0.551; P = 0.001 and r = 0.343, respectively). The impact of the visual field on vision-related QOL increased in the advanced stages ( P = 0.013, r = 0.688). The macular retinal ganglion cell plus inner plexiform layer thickness remained associated with NEI-VFQ-25 at all stages of glaucoma ( r = 0.335 to 0.802). The NEI-VFQ-25 total score and most of the subscales were correlated with the physical and mental component summary scores of the SF-36 ( r = 0.159 to 0.587).
Visual acuity correlated the most with QOL in patients with glaucoma, as measured with the NEI-VFQ-25 to assess QOL in glaucoma. The impact of visual functions on QOL varies at different stages of glaucoma.
除了标准的自动视野测试外，对比敏感度（CS）测试和黄斑分析可能预测青光眼不同阶段患者的生活质量（QOL）变化。
研究青光眼不同阶段患者视觉功能的功能和结构测试与25项美国国立眼科研究所视觉功能问卷（NEI-VFQ-25）以及36项简明健康调查问卷（SF-36）之间的关系。
对160例青光眼患者前瞻性地进行标准自动视野测试、光学相干断层扫描和CS测试。采用Hoddap-Parrish-Anderson分期系统对青光眼进行分期。还对所有患者进行了与健康相关的生活质量问卷（NEI-VFQ-25、SF-36）调查。
研究组包括29例疑似青光眼患者、104例轻度青光眼患者、15例中度青光眼患者和12例重度青光眼患者。NEI-VFQ-25的平均总分是88.8±8.2。SF-36与视觉功能的功能和结构测试数据无显著相关性，而NEI-VFQ-25显示出低至中度相关性（r = 0.212至 -0.492）。视力参数可解释NEI-VFQ-25总分的18.6%。CS是与疑似青光眼患者唯一显著相关的功能，而在早期，视力是与NEI-VFQ-25总分相关性最强的功能（分别为P = 0.003，r = 0.551；P = 0.001，r = 0.343）。在晚期，视野对视力相关生活质量的影响增加（P = 0.013，r = 0.688）。在青光眼的所有阶段，黄斑视网膜神经节细胞加内丛状层厚度均与NEI-VFQ-25相关（r = 0.335至0.802）。NEI-VFQ-25总分和大多数子量表与SF-36的身体和精神成分总结得分相关（r = 0.159至0.587）。
用NEI-VFQ-25评估青光眼患者的生活质量时，视力与生活质量的相关性最高。视觉功能对生活质量的影响在青光眼的不同阶段有所不同。
