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亚铁死亡相关基因 DUOX1 和 HSD17B11 影响肺腺癌患者的肿瘤微环境并预测其总生存期。

Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients.

机构信息

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Cancer Hospital, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

出版信息

Medicine (Baltimore). 2024 May 31;103(22):e38322. doi: 10.1097/MD.0000000000038322.

DOI:10.1097/MD.0000000000038322
PMID:39259123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11142834/
Abstract

BACKGROUND

Recent studies have found that ferroptosis-related genes (FRGs) have broad applications in tumor therapy. However, the predictive potential of these genes in lung adenocarcinoma (LUAD) remains to be fully characterized. We aimed to investigate the FRGs that might be potential targets for LUAD.

METHODS

We screened the RNA sequencing samples from LUAD patients from the GEO database and analyzed the ferroptosis-related differentially expressed genes (DEGs). A functional analysis of DEGs was performed. The risk model was constructed to evaluation and validation FRGs. We explored the immune landscape of LUAD and controls. The value of FRGs in diagnosing LUAD was tested in the GSE30219, GSE37745, GSE0081 datasets, and qPCR was used to verify their diagnostic value in LUAD patients in our hospital.

RESULTS

A total of 1327 DEGs in quantitative proteomics were obtained, of which ferroptosis-related DEGs were 259. Enrichment analysis showed significant enrichment in the absorption and metabolism of fatty acids and arachidonic acid. The upregulated genes (GCLC, RRM2, AURKA, SLC7A5, and SLC2A1) and downregulated genes (ANGPTL7, ALOX15, ALOX15B, HSD17B11, IL33, TSC22D3, and DUOX1) were selected as core genes in tissue samples from 62 patients by qPCR. DUOX1 and HSD17B11 were obtained by bioinformatics analysis, both of which showed similar expression trends at the RNA and protein levels. The Kaplan-Meier method showed that DUOX1 and HSD17B11 were closely related to the overall survival (OS) of LUAD patients.

CONCLUSION SUBSECTIONS

Ferroptosis-related genes DUOX1 and HSD17B11 are of considerable value in the diagnosis of LUAD patients. Their low expression suggests an increased recurrence rate and leads to a decrease in the patient quality of life.

摘要

背景

最近的研究发现，铁死亡相关基因（FRGs）在肿瘤治疗中有广泛的应用。然而，这些基因在肺腺癌（LUAD）中的预测潜力仍有待充分描述。我们旨在研究可能成为 LUAD 潜在靶点的 FRGs。

方法

我们从 GEO 数据库中筛选 LUAD 患者的 RNA 测序样本，并分析铁死亡相关差异表达基因（DEGs）。对 DEGs 进行功能分析。构建风险模型以评估和验证 FRGs。我们探索了 LUAD 和对照的免疫景观。在 GSE30219、GSE37745、GSE0081 数据集以及 qPCR 中测试 FRGs 诊断 LUAD 的价值，并在我院 LUAD 患者中验证其诊断价值。

结果

定量蛋白质组学中获得了 1327 个 DEGs，其中铁死亡相关 DEGs 为 259 个。富集分析显示，在脂肪酸和花生四烯酸的吸收和代谢中存在显著富集。通过 qPCR 在 62 例患者的组织样本中选择上调基因（GCLC、RRM2、AURKA、SLC7A5 和 SLC2A1）和下调基因（ANGPTL7、ALOX15、ALOX15B、HSD17B11、IL33、TSC22D3 和 DUOX1）作为核心基因。通过生物信息学分析获得 DUOX1 和 HSD17B11，它们在 RNA 和蛋白质水平上均显示出相似的表达趋势。Kaplan-Meier 方法显示，DUOX1 和 HSD17B11 与 LUAD 患者的总生存期（OS）密切相关。

结论

铁死亡相关基因 DUOX1 和 HSD17B11 在 LUAD 患者的诊断中有重要价值。它们的低表达表明复发率增加，导致患者生活质量下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/9e222020018a/medi-103-e38322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/85db8343c348/medi-103-e38322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/454324e5f7c1/medi-103-e38322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/5b5bd9536070/medi-103-e38322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/0415b0e3c4c8/medi-103-e38322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/30749f843dfe/medi-103-e38322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/9e222020018a/medi-103-e38322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/85db8343c348/medi-103-e38322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/454324e5f7c1/medi-103-e38322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/5b5bd9536070/medi-103-e38322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/0415b0e3c4c8/medi-103-e38322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/30749f843dfe/medi-103-e38322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4162/11142834/9e222020018a/medi-103-e38322-g006.jpg

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本文引用的文献

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Front Oncol. 2023 Mar 17;13:1085581. doi: 10.3389/fonc.2023.1085581. eCollection 2023.
2
Identification MNS1, FRZB, OGN, LUM, SERP1NA3 and FCN3 as the potential immune-related key genes involved in ischaemic cardiomyopathy by random forest and nomogram.通过随机森林和列线图鉴定 MNS1、FRZB、OGN、LUM、SERP1NA3 和 FCN3 为潜在的与免疫相关的缺血性心肌病关键基因。
Aging (Albany NY). 2023 Feb 27;15(5):1475-1495. doi: 10.18632/aging.204547.
3
Cancer statistics, 2023.
癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
4
Engineering Alendronate-Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment.工程化阿仑膦酸盐组成的铁纳米螯合剂用于高效腹腔癌转移治疗。
Adv Sci (Weinh). 2022 Oct;9(30):e2203031. doi: 10.1002/advs.202203031. Epub 2022 Sep 4.
5
Induction of Ferroptosis by Ophiopogonin-B Through Regulating the Gene Signature in NSCLC.麦冬皂苷B通过调控非小细胞肺癌中的基因特征诱导铁死亡
Front Oncol. 2022 Jun 28;12:833814. doi: 10.3389/fonc.2022.833814. eCollection 2022.
6
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.m6A去甲基化酶FTO通过调节食管癌中的脂质代谢促进肿瘤进展。
Cell Biosci. 2022 May 14;12(1):60. doi: 10.1186/s13578-022-00798-3.
7
Development and Validation of Ferroptosis-Related LncRNA Biomarker in Bladder Carcinoma.膀胱癌中铁死亡相关长链非编码RNA生物标志物的开发与验证
Front Cell Dev Biol. 2022 Mar 2;10:809747. doi: 10.3389/fcell.2022.809747. eCollection 2022.
8
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance.铁死亡在癌症治疗中的作用：逆转耐药性的新策略
Mol Cancer. 2022 Feb 12;21(1):47. doi: 10.1186/s12943-022-01530-y.
9
Ferroptosis in cancer and cancer immunotherapy.铁死亡在癌症和癌症免疫治疗中的作用。
Cancer Commun (Lond). 2022 Feb;42(2):88-116. doi: 10.1002/cac2.12250.
10
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy.肿瘤微环境中的铁死亡：免疫治疗的新视角。
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