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二尖瓣和三尖瓣联合瓣膜手术后永久性心脏起搏器植入:一项全国多中心研究。

Permanent pacemaker implantation after combined mitral- and tricuspid valve surgery: a nationwide multicentre study.

机构信息

Department of Cardiothoracic Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.

Department of Cardiothoracic Surgery, Isala Heart Centre, Zwolle, The Netherlands.

出版信息

Eur J Cardiothorac Surg. 2024 Oct 1;66(4). doi: 10.1093/ejcts/ezae328.

Abstract

OBJECTIVES

The threshold to perform concomitant tricuspid valve (TV) repair during primary mitral valve (MV) surgery has decreased, based on recent randomized evidence. Based on these developments, the indication for TV repair during MV surgery is expected to increase further. However, concerns have been raised regarding the risk of permanent pacemaker implantation (PPI) during a concomitant procedure. Therefore, we aim to assess the incidence of PPI in combined MV and TV surgery in a nationwide registry.

METHODS

The current study uniquely cross-linked the Cardiothoracic and Pacemaker/ICD registry of the Netherlands Heart Registration. Patients undergoing primary MV and TV surgery (± atrial septal defect closure, rhythm surgery, coronary artery bypass grafting) between 1 January and 31 December2021 were included. The primary outcome was PPI within 30 days after surgery. Subgroup analyses were performed for isolated MV and TV surgery and MV repair. The association between concomitant TV surgery and PPI was assessed using multivariable binary logistic regression analyses.

RESULTS

A total of 1060 patients (n = 833 MV, n = 227 MV + TV) were included. The overall incidence of PPI was 4.3%. No significant difference in PPI between MV and MV + TV surgery were found (3.7% vs 6.6%, P = 0.06). Concomitant TV surgery was not an independent risk factor for PPI after surgery after adjustment for covariates. These results were robust after sensitivity analyses.

CONCLUSIONS

The current study was not able to find a statistical difference between the PPI rate in MV surgery patients and MV + TV surgery patients. Extension of the waiting period prior to PPI, may result in decreased PPI rates.

摘要

目的

基于最近的随机证据,在初次二尖瓣(MV)手术中同时进行三尖瓣(TV)修复的阈值已经降低。基于这些发展,预计 MV 手术中 TV 修复的适应证将进一步扩大。然而,人们对同期手术中永久性心脏起搏器植入(PPI)的风险表示担忧。因此,我们旨在全国注册中心评估联合 MV 和 TV 手术中 PPI 的发生率。

方法

本研究独特地交叉链接了荷兰心脏登记处的心胸外科和起搏器/ICD 登记处。纳入 2021 年 1 月 1 日至 12 月 31 日期间接受原发性 MV 和 TV 手术(±房间隔缺损闭合、节律手术、冠状动脉旁路移植术)的患者。主要结局是手术后 30 天内的 PPI。对单独的 MV 和 TV 手术以及 MV 修复进行了亚组分析。使用多变量二项逻辑回归分析评估同期 TV 手术与 PPI 之间的关系。

结果

共纳入 1060 例患者(n=833例 MV,n=227 例 MV+TV)。PPI 的总体发生率为 4.3%。MV 手术和 MV+TV 手术之间的 PPI 发生率无显著差异(3.7%比 6.6%,P=0.06)。调整协变量后,同期 TV 手术不是术后 PPI 的独立危险因素。这些结果在敏感性分析后仍然稳健。

结论

本研究未能发现 MV 手术患者和 MV+TV 手术患者的 PPI 发生率之间存在统计学差异。延长 PPI 前的等待期可能会降低 PPI 率。

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