Jansson Daniel, Lundberg Elena, Rullander Anna-Clara, Domellöf Magnus, Lindberg Ann-Sofie, Andersson Helena, Theos Apostolos
Department of Community Medicine & Rehabilitation, Section of Sports Medicine, Umeå University, Linnaeus Väg 9, 90187, Umeå, Sweden.
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Eur J Appl Physiol. 2025 Feb;125(2):381-392. doi: 10.1007/s00421-024-05603-2. Epub 2024 Sep 11.
Examine the acute hormonal and cytokine responses to free-weight resistance training in trained prepubertal and pubertal male children.
Prepubertal (n = 21; age 11.4 ± 1.1 years; Tanner I-II) and pubertal male children (n = 20; age 15.8 ± 0.7 years; Tanner III-V) conducted a moderate-intensity free-weight resistance training program to failure with venous blood sampling before (pre), immediately after (post) and during the recovery phase of the program (post-15,-30 min). Growth hormone (GH), insulin-like growth factor-I (IGF-I), cortisol, testosterone, IL-6, and TNF-α were analyzed in serum samples. Biological maturation was assessed according to the stages of the Tanner scale.
There was a significant time-by-group interaction in IGF-I response (p = 0.044; η = 0.209) and testosterone (p < 0.001; η = 0.508), indicating a greater change in the pubertal group compared to the prepubertal group. Both groups significantly increased post-exercise GH levels (p < 0.05). Only the prepuberal group significantly increased levels of IL-6 at all post-exercise time points (p < 0.05). Both groups showed a significant (p < 0.05) increase in TNF-α levels compared to resting levels.
These data suggest that acute testosterone and IGF-I response following resistance training differ between trained prepubertal and pubertal male children. Moderate-intensity resistance training performed to failure may thus have different effects in trained prepubertal and pubertal male children, which should be considered when giving training advice.
Clinical trials number: NCT05022992.
研究青春期前和青春期受过训练的男性儿童对自由重量抗阻训练的急性激素和细胞因子反应。
青春期前男性儿童（n = 21；年龄11.4 ± 1.1岁；坦纳I-II期）和青春期男性儿童（n = 20；年龄15.8 ± 0.7岁；坦纳III-V期）进行了中等强度的自由重量抗阻训练计划，直至力竭，并在训练前（pre）、训练后立即（post）以及训练恢复阶段（post-15、-30分钟）采集静脉血样。分析血清样本中的生长激素（GH）、胰岛素样生长因子-I（IGF-I）、皮质醇、睾酮、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。根据坦纳量表的阶段评估生物成熟度。
IGF-I反应（p = 0.044；η = 0.209）和睾酮（p < 0.001；η = 0.508）存在显著的组间时间交互作用，表明青春期组比青春期前组的变化更大。两组运动后GH水平均显著升高（p < 0.05）。只有青春期前组在所有运动后时间点IL-6水平均显著升高（p < 0.05）。与静息水平相比，两组TNF-α水平均显著升高（p < 0.05）。
这些数据表明，青春期前和青春期受过训练的男性儿童在抗阻训练后的急性睾酮和IGF-I反应有所不同。因此，进行至力竭的中等强度抗阻训练对青春期前和青春期受过训练的男性儿童可能有不同影响，在提供训练建议时应予以考虑。
临床试验编号：NCT05022992。
