Hirschauer Pomme, Paris Benoît, Messaoudene Sonia, Fournier Maryse, Bourlon Bertrand, Hou Yanxia, Ricoul Florence, Laplatine Loïc
Univ. Grenoble Alpes, CEA, LETI, Grenoble, 38054, France.
Univ. Grenoble Alpes, CEA, CNRS, Grenoble INP, IRIG, SyMMES, 38000, Grenoble, France.
Talanta. 2025 Jan 1;281:126659. doi: 10.1016/j.talanta.2024.126659. Epub 2024 Aug 2.
Gas chromatography is a reference method for gas analysis. As part of efforts to miniaturize gas chromatography systems, the miniaturization of detectors is essential. In this work, we report a new integrated photonic platform for gas chromatography analyte detection. The fabricated silicon die integrates Mach-Zehnder interferometers into low dead volume microfluidic channels, with coherent cost-effective detection scheme with a fixed 850 nm wavelength laser. A proof of concept is demonstrated with the separation and detection of three volatile organic compounds: heptane, octane, and toluene. Peaks' widths at half height range from 1 to 5 s. Peaks are very well resolved by our system, which acquires more than 100 points per second. From a heptane dilution range, we evaluate the limit of detection of our system to be the headspace of a 0.26 % heptane concentration solution. To our knowledge, these are the first integrated Mach-Zehnder interferometers reported for gas chromatography detection. This work could open new strategies for fast low cost and low limit of detection specific gas chromatography silicon micro-detectors.
气相色谱法是气体分析的一种参考方法。作为气相色谱系统小型化努力的一部分，检测器的小型化至关重要。在这项工作中，我们报告了一种用于气相色谱分析物检测的新型集成光子平台。制造的硅芯片将马赫-曾德尔干涉仪集成到低死体积微流控通道中，采用固定850 nm波长激光的相干且经济高效的检测方案。通过分离和检测三种挥发性有机化合物：庚烷、辛烷和甲苯，证明了概念验证。半高峰宽范围为1至5秒。我们的系统能很好地分辨出这些峰，该系统每秒采集超过100个点。从庚烷稀释范围来看，我们评估我们系统的检测限为0.26%庚烷浓度溶液的顶空。据我们所知，这些是首次报道用于气相色谱检测的集成马赫-曾德尔干涉仪。这项工作可为快速、低成本且检测限低的特定气相色谱硅微检测器开辟新策略。
