IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Cell Rep Med. 2024 Sep 17;5(9):101737. doi: 10.1016/j.xcrm.2024.101737. Epub 2024 Sep 10.
Since the nineties, the incidence of sporadic early-onset (EO) cancers has been rising worldwide. The underlying reasons are still unknown. However, identifying them is vital for advancing both prevention and intervention. Here, we exploit available knowledge derived from clinical observations to formulate testable hypotheses aimed at defining the causal factors of this epidemic and discuss how to experimentally test them. We explore the potential impact of exposome changes from the millennials to contemporary young generations, considering both environmental exposures and enhanced susceptibilities to EO-cancer development. We emphasize how establishing the time required for an EO cancer to develop is relevant to defining future screening strategies. Finally, we discuss the importance of integrating multi-dimensional data from international collaborations to generate comprehensive knowledge and translate these findings back into clinical practice.
自 90 年代以来，散发性早发（EO）癌症的发病率在全球范围内呈上升趋势。其根本原因尚不清楚。然而，识别这些原因对于推进预防和干预至关重要。在这里，我们利用从临床观察中获得的现有知识，制定可检验的假设，旨在确定这一流行的因果因素，并讨论如何对其进行实验检验。我们探讨了从千禧一代到当代年轻一代的外显子组变化的潜在影响，同时考虑了环境暴露和对 EO 癌症发展的易感性增强。我们强调了确定 EO 癌症发展所需时间对于定义未来的筛查策略的重要性。最后，我们讨论了整合来自国际合作的多维数据以生成全面知识并将这些发现转化回临床实践的重要性。
