Zhang Lele, Zhang Yuzhe, Chen Lei, Wang Xu, Liu Yulian, Huang Yishan, Song Yu, Zhang Ye, Tai Jiandong
Department of Colorectal & Anal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, China.
Front Oncol. 2025 May 14;15:1492880. doi: 10.3389/fonc.2025.1492880. eCollection 2025.
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. The current standard of care for patients with early-stage CRC includes surgical resection and, in selected patients, adjuvant chemotherapy. Circulating tumor DNA (ctDNA) testing is an important component of liquid biopsy, and with the development of testing technology, its value for clinical application has attracted widespread attention. The aim of this study was to help researchers review what has been achieved and better understand the direction of future research through bibliometric analysis.
We used the Web of Science Core Collection database to search for ctDNA in CRC-related articles published between 2014 - 2023. Bibliometric analyses of major keywords, authors, countries, institutions, literature and journals in the field were performed using CiteSpace and VOSviewer.
The number of publications in the field has continued to increase over the last decade. The United States has the highest number of publications, and Italian research scholars have made outstanding contributions. Cancers is the journal with the highest number of publications.
This study systematically summarizes the research findings in the field of ctDNA in CRC from 2014 to 2023 and describes the research hotspots and trends worldwide that can guide future research.
结直肠癌（CRC）是全球第三大常见癌症，也是癌症相关死亡的第二大主要原因。早期CRC患者目前的标准治疗包括手术切除，部分患者还需辅助化疗。循环肿瘤DNA（ctDNA）检测是液体活检的重要组成部分，随着检测技术的发展，其临床应用价值受到广泛关注。本研究的目的是通过文献计量分析，帮助研究人员回顾已取得的成果，并更好地理解未来研究方向。
我们使用Web of Science核心合集数据库检索2014年至2023年间发表的与CRC相关的文章中关于ctDNA的内容。使用CiteSpace和VOSviewer对该领域的主要关键词、作者、国家、机构、文献和期刊进行文献计量分析。
在过去十年中，该领域的出版物数量持续增加。美国的出版物数量最多，意大利研究学者做出了突出贡献。《Cancers》是发表文章数量最多的期刊。
本研究系统总结了2014年至2023年CRC领域ctDNA的研究成果，描述了全球范围内的研究热点和趋势，可为未来研究提供指导。
