Blake P R, Catterall M, Errington R D
Br J Surg. 1985 Jul;72(7):517-9. doi: 10.1002/bjs.1800720704.
Fast neutron therapy has been used to treat 87 tumours of primary, recurrent or metastatic melanoma in 48 patients. Complete regression has been obtained in 71 percent of tumours and 91 per cent of all tumours were controlled for the remainder of the patients, lives. Median survival was 14.5 months; 30 of the 34 deaths were due to metastases. Complications arose in 22 per cent of sites and were either fibrosis, which was related to large treated areas, previous surgery or a higher than standard dose, or necrosis which was related to sites with poor circulation, such as in the lower limb. It is suggested that for the treatment of advanced local disease fast neutron therapy is more effective than X-ray treatment and has a local control rate similar to that of surgery.
快中子疗法已用于治疗48例患者的87处原发性、复发性或转移性黑色素瘤肿瘤。71%的肿瘤实现了完全消退，其余患者中91%的所有肿瘤得到控制，患者存活。中位生存期为14.5个月；34例死亡中有30例死于转移。22%的治疗部位出现并发症，要么是纤维化，这与治疗面积大、既往手术或高于标准剂量有关，要么是坏死，这与血液循环差的部位有关，如下肢。有人认为，对于晚期局部疾病的治疗，快中子疗法比X射线治疗更有效，局部控制率与手术相似。
