Overgaard J, von der Maase H, Overgaard M
Int J Radiat Oncol Biol Phys. 1985 Oct;11(10):1837-9. doi: 10.1016/0360-3016(85)90042-2.
Thirty-five tumors in 14 patients with metastatic or recurrent malignant melanoma were randomized to high dose per fraction radiotherapy at either 9 Gy X 3 or 5 Gy X 8 twice weekly. Complete and persistent regression was found in 24/35 (69%) and partial response in 10/35 of the tumors. The overall response rate was 97%. No difference was observed between the two treatment regimens. Acute and late radiation damage to normal tissue was acceptable and of the same magnitude in both schedules.
