Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167500. doi: 10.1016/j.bbadis.2024.167500. Epub 2024 Sep 10.
The viral replication can impress through cellular miRNAs. Indeed, either the antiviral responses or the viral infection changes through cellular miRNAs resulting in affecting many regulatory signaling pathways. One of the microRNA families that is effective in human cancers, diseases, and viral infections is the miR-29 family. Members of miR-29 family are effective in different viral infections as their roles have appeared in regulation of immunity pathways either in innate immunity including interferon and inflammatory pathways or in adaptive immunity including activation of T-cells and antibodies production. Although miR-29a affects viral replication by suppressing antiviral responses, it can inhibit the expression of viral mRNAs via binding to their 3'UTR. In the present work, we discuss the evidence related to miR-29a and viral infection through host immunity regulation. We also review roles of other miR-29 family members by focusing on their role as biomarkers for diagnosing and targets for viral diseases management.
病毒复制可以通过细胞 miRNA 产生影响。事实上，细胞 miRNA 的抗病毒反应或病毒感染的变化会导致许多调节信号通路受到影响。miR-29 家族是在人类癌症、疾病和病毒感染中起作用的 miRNA 家族之一。miR-29 家族的成员在不同的病毒感染中都很有效，因为它们的作用已经出现在免疫途径的调节中，包括先天免疫，包括干扰素和炎症途径，或在适应性免疫中，包括 T 细胞的激活和抗体的产生。尽管 miR-29a 通过抑制抗病毒反应来影响病毒复制，但它可以通过与 3'UTR 结合来抑制病毒 mRNA 的表达。在本工作中，我们通过宿主免疫调节讨论了与 miR-29a 和病毒感染相关的证据。我们还通过关注其他 miR-29 家族成员作为诊断标志物和病毒疾病管理靶点的作用来综述它们的作用。
