Sumarac Srdjan, Youn Jinyoung, Fearon Conor, Zivkovic Luka, Keerthi Prerana, Flouty Oliver, Popovic Milos, Hodaie Mojgan, Kalia Suneil, Lozano Andres, Hutchison William, Fasano Alfonso, Milosevic Luka
Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
NPJ Parkinsons Dis. 2024 Sep 12;10(1):175. doi: 10.1038/s41531-024-00773-4.
Parkinson's disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12-21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4-8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21-30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.
帕金森病（PD）与基底神经节内的病理性神经活动有关。在此，我们分析了接受丘脑底核（STN；n = 125）或苍白球内侧部（GPi；n = 44）清醒状态下深部脑刺激手术的帕金森病患者的静息态单神经元和局部场电位（LFP）活动，并将基于速率的特征和振荡特征与非药物状态下的统一帕金森病评定量表第三部分（UPDRSIII）子评分进行关联。基于速率的单神经元特征与帕金森病症状不相关。STN单神经元和LFP的低β（12 - 21Hz）功率及爆发动力学与运动迟缓及强直严重程度呈适度相关，而STN尖峰序列θ（4 - 8Hz）功率与震颤严重程度呈适度相关。GPi的低β和高β（21 - 30Hz）功率及爆发动力学与运动迟缓及轴向症状严重程度呈中度相关。这些发现表明，单神经元和LFP振荡增强可能与症状有关，尽管适度的相关性意味着帕金森病的病理生理学可能超出静息态β振荡的范围。
