Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
Khyber Medical College, Peshawar, Pakistan.
J Pak Med Assoc. 2024 Mar;74(3 (Supple-3)):S30-S51. doi: 10.47391/JPMA.S3.GNO-06.
Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review was designed to discuss current updates in liquid biopsy tools for diagnosis and guiding clinical management of brain tumours; we evaluated the literature within the context of low-and-middle-income country challenges. Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), cell-free DNA (cfDNA), extracellular vesicle-associated biomarkers, protein biomarkers, microRNAs, and serum metabolites are discussed with the collation of current data supporting their utility in liquid biopsy. Further challenges to implanting liquid biopsy tools at a systematic level are highlighted.
脑部肿瘤的诊断和治疗后复发的检测方法既昂贵又具有显著的侵袭性。开发外周样本液体活检工具是提高我们预测脑肿瘤亚型和分子异质性能力的关键。本范围综述旨在讨论液体活检工具在诊断和指导脑肿瘤临床管理方面的最新进展；我们评估了文献，考虑了中低收入国家面临的挑战。本文讨论了循环肿瘤细胞（CTC）、循环肿瘤 DNA（ctDNA）、游离 DNA（cfDNA）、细胞外囊泡相关生物标志物、蛋白质生物标志物、microRNAs 和血清代谢物，并汇集了目前支持其在液体活检中应用的数据。还强调了在系统层面上实施液体活检工具所面临的进一步挑战。
