Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Otolaryngology-Head & Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Biomark Med. 2020 Oct;14(14):1393-1404. doi: 10.2217/bmm-2020-0022. Epub 2020 Oct 19.
Head and neck cancer (HNC) is the sixth leading cause of cancer death worldwide. Due to the low early diagnosis rate of HNC, local recurrence and high distant metastasis rate are the main reasons for treatment failure. Therefore, it is important to establish a method of diagnosis and monitoring, which is convenient, safe, reproducible, sensitive and specific. Compared with tissue biopsy, liquid biopsy is an emerging biopsy technique, which has the advantages of re-sampling, noninvasive and cost-effectiveness, and has shown good diagnostic and prognostic value in studies for various types of malignant solid tumors. This review introduces liquid biopsy, its research progress and prospects in HNC including early diagnosis, staging, grading, prognosis assessment and disease surveillance.
头颈部癌症（HNC）是全球第六大癌症死亡原因。由于 HNC 的早期诊断率较低，局部复发和高远处转移率是治疗失败的主要原因。因此，建立一种方便、安全、可重复、敏感和特异的诊断和监测方法非常重要。与组织活检相比，液体活检是一种新兴的活检技术，具有可重复采样、非侵入性和成本效益高的优点，在各种恶性实体瘤的研究中显示出良好的诊断和预后价值。本综述介绍了液体活检及其在 HNC 中的早期诊断、分期、分级、预后评估和疾病监测方面的研究进展和前景。
