Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Autism Res. 2022 Dec;15(12):2399-2408. doi: 10.1002/aur.2831. Epub 2022 Oct 17.
Previous research has identified that patterns of cooccurring conditions (CoCs) associated with autism spectrum disorder (ASD) differ based on the presence of intellectual disability (ID). This study explored the association of documented CoCs among 8-year-old children with ASD and ID (ASD+ID, n = 2416) and ASD without ID (ASD-ID, n = 5372) identified by the Autism and Developmental Disabilities Monitoring Network, surveillance years (SYs) 2012 and 2014. After adjusting for demographic variables, record source, surveillance site, and SY, children with ASD+ID, as compared with children with ASD-ID, were more likely to have histories of nonspecific developmental delays and neurological disorders documented in their records but were less likely to have behavioral and psychiatric disorders. ID plays a key role on how children with ASD would experience other CoCs. Our results emphasize how understanding the pattern of CoCs in ASD+ID and ASD-ID can inform comprehensive and multidisciplinary approaches in assessment and management of children in order to develop targeted interventions to reduce possible CoCs or CoCs-related impairments.
先前的研究已经确定,与自闭症谱系障碍(ASD)相关的共病模式(CoCs)因智力障碍(ID)的存在而有所不同。本研究通过自闭症及发育障碍监测网络(Autism and Developmental Disabilities Monitoring Network)在 2012 年和 2014 年的监测年度(SYs)中对 8 岁患有 ASD 且有 ID(ASD+ID,n=2416)和无 ID(ASD-ID,n=5372)的儿童进行记录,探讨了这些儿童共病情况的相关性。在调整人口统计学变量、记录来源、监测地点和 SY 后,与 ASD-ID 患儿相比,ASD+ID 患儿的记录中更有可能出现非特定发育迟缓史和神经系统疾病史,但行为和精神疾病史较少。ID 对 ASD 患儿经历其他共病的方式起着关键作用。我们的研究结果强调了理解 ASD+ID 和 ASD-ID 中 CoCs 模式的重要性,这可以为儿童的评估和管理提供全面和多学科的方法,以便制定有针对性的干预措施,以减少可能的共病或共病相关障碍。