Liu Xiangyan, Tao Ran, Guo Fangrui, Zhang Linyu, Qu Jianyu, Li Mengyao, Wu Xiaoran, Wang Xianglin, Zhu Yuanyuan, Wen Lixin, Wang Ji
Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Changsha Lvye Biotechnology Co., Ltd., Changsha, 410100, China.
J Tradit Complement Med. 2024 Feb 29;14(5):522-533. doi: 10.1016/j.jtcme.2024.02.002. eCollection 2024 Sep.
Neuroinflammation is considered the principal pathogenic mechanism underlying neurodegenerative diseases, and the incidence of brain disorders is closely linked to dietary fat consumption and intestinal health. To investigate this relationship, 60 8-week-old C57BL/6J mice were subjected to a 20-week dietary intervention, wherein they were fed lard and soybean oil, each at 15% and 35% fat energy. At a dietary fat energy level of 35%, inflammation was observed in both the soybean oil and lard groups. Nevertheless, inflammation was more pronounced in the mice that were administered soybean oil. The process by which nerve cell structure is compromised, inflammatory factors are upregulated, brain antioxidant capacity is diminished, and the TLR4/MyD88/NF-κB p65 inflammatory pathway is activated resulting in damage to the brain-gut barrier. This, in turn, leads to a reduction in the abundance of and , as well as an increase in abundance, ultimately resulting in brain inflammation and damage. These results suggested that soybean oil induces more severe neuroinflammation compared to lard. Our study demonstrated that, at a dietary fat energy level of 35%, compared to soybean oil, lard could be the healthier option, the outcomes would help provide a reference basis for the selection of residents' daily dietary oil.
神经炎症被认为是神经退行性疾病的主要致病机制，脑部疾病的发病率与膳食脂肪摄入和肠道健康密切相关。为了研究这种关系，对60只8周龄的C57BL/6J小鼠进行了为期20周的饮食干预，给它们喂食猪油和大豆油，脂肪能量各占15%和35%。在膳食脂肪能量水平为35%时，大豆油组和猪油组小鼠均出现炎症。然而，喂食大豆油的小鼠炎症更为明显。神经细胞结构受损、炎症因子上调、脑抗氧化能力下降以及TLR4/MyD88/NF-κB p65炎症通路被激活，从而导致脑-肠屏障受损。这反过来又导致了[此处原文缺失相关物质名称]丰度降低以及[此处原文缺失相关物质名称]丰度增加，最终导致脑部炎症和损伤。这些结果表明，与猪油相比，大豆油会引发更严重的神经炎症。我们的研究表明，在膳食脂肪能量水平为35%时，与大豆油相比，猪油可能是更健康的选择，这一结果将有助于为居民日常食用油的选择提供参考依据。
