Xu Ligong, Shi Jingjing, Wu Shuang
Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou, Zhejiang, China.
Am J Transl Res. 2024 Aug 15;16(8):3534-3544. doi: 10.62347/CIUT6327. eCollection 2024.
Stem cells possess unique self-renewal and differentiation capacities, that are central to cell replacement and tissue regeneration. The therapeutic potential of stem cell applications has garnered increasing attention in recent years for a spectrum of human diseases, from ischemic disorders to oncological challenges. Despite their potential, a comprehensive understanding of the biological behavior, efficacy, and safety of these cells remains elusive, hindering their clinical adoption. This review focuses on the use of positron emission tomography (PET) imaging as a cutting-edge tool for bridging this knowledge gap. PET imaging, a noninvasive diagnostic method, has been highlighted for its ability to monitor cellular dynamics after stem cell transplantation. A variety of molecular probes within the PET framework enable the longitudinal and quantitative evaluation of post-transplant cellular behavior. This discourse systematically delineates various PET probes specifically designed for the tracking of the stem cell life cycle. These probes offer a pathway to a deeper understanding and more precise evaluation of stem cell behavior post-transplantation. Implementing PET imaging probes can revolutionize the clinical understanding of stem cell behavior, advancing and widening clinical therapeutic applications.
干细胞具有独特的自我更新和分化能力，这对于细胞替代和组织再生至关重要。近年来，干细胞应用的治疗潜力在一系列人类疾病中，从缺血性疾病到肿瘤挑战，都受到了越来越多的关注。尽管它们具有潜力，但对这些细胞的生物学行为、疗效和安全性的全面理解仍然难以捉摸，这阻碍了它们在临床上的应用。本综述重点介绍了正电子发射断层扫描（PET）成像作为一种前沿工具来弥合这一知识差距的应用。PET成像作为一种非侵入性诊断方法，因其能够监测干细胞移植后的细胞动态而受到关注。PET框架内的各种分子探针能够对移植后的细胞行为进行纵向和定量评估。本文系统地描述了专门设计用于追踪干细胞生命周期的各种PET探针。这些探针为更深入地理解和更精确地评估移植后干细胞行为提供了一条途径。实施PET成像探针可以彻底改变对干细胞行为的临床理解，推动并拓宽临床治疗应用。
