Department of Immunology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China.
Respiratory Diseases, Shandong Second Provincial General Hospital, Shandong University, Jinan, China.
Cell Mol Biol Lett. 2022 Aug 19;27(1):69. doi: 10.1186/s11658-022-00366-0.
Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tissue homeostasis, aging-related diseases, and cellular therapy is clinically suggested. As aging is a universal problem that has large socioeconomic effects, an improved understanding of the concepts of aging can direct public policies that reduce its adverse impacts on the healthcare system and humanity. Several studies of aging have been carried out over several years to understand the phenomenon and different factors affecting human aging. A reduced ability of adult stem cell populations to reproduce and regenerate is one of the main contributors to the human aging process. In this context, MSCs senescence is a major challenge in front of cellular therapy advancement. Many factors, ranging from genetic and metabolic pathways to extrinsic factors through various cellular signaling pathways, are involved in regulating the mechanism of MSC senescence. To better understand and reverse cellular senescence, this review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellular senescence.
人骨髓间充质干细胞（MSCs）是主要的多能细胞，在适当条件下刺激时能够分化为成骨细胞、软骨细胞和成脂细胞。MSCs 在组织稳态、与衰老相关的疾病和细胞治疗中的作用在临床上得到了提示。由于衰老是一个普遍存在的问题，对社会经济有很大影响，因此，更好地理解衰老的概念可以指导公共政策，减少其对医疗保健系统和人类的不利影响。多年来，已经进行了多项关于衰老的研究，以了解这一现象和影响人类衰老的不同因素。成年干细胞群体繁殖和再生能力的降低是人类衰老过程的主要原因之一。在这种情况下，MSC 衰老成为细胞治疗进展的主要挑战。许多因素，从遗传和代谢途径到通过各种细胞信号通路的外在因素，都参与调节 MSC 衰老的机制。为了更好地理解和逆转细胞衰老，本综述强调了 MSC 细胞衰老的潜在机制和迹象，并讨论了对抗衰老和细胞衰老的策略。
