Yu Fujie, Li Yuanmei, Zou Jiaqun, Jiang Lisha, Wang Chun, Tang Yi, Gao Bo, Luo Donglin, Jiang Xiaojuan
Breast Thyroid Surgery, Army Military University Daping Hospital Institute of Field Surgery, Chongqing, China.
J Int Med Res. 2019 Jun;47(6):2607-2614. doi: 10.1177/0300060519842781. Epub 2019 May 17.
To investigate the effects of the Chinese herbal medicine Xiaoaiping to treat chemotherapy-induced side effects in breast cancer patients.
Ninety-three adult patients who attended our hospital and met the entry criteria from January 2016 to December 2017 were included. Patients were randomly divided into the control group (routine chemotherapy only) and the combined group (routine chemotherapy and Xiaoaiping). Demographic data and clinical variables were collected, and side effects including alopecia, nausea and vomiting, diarrhea, white blood cell (WBC) count, aspartate aminotransferase (AST) levels, and the quality of life were evaluated.
Basic clinical characteristics were not different between the groups. There were significantly fewer patients with alopecia grade 3-4, but significantly more patients with alopecia grade 1-2, in the combined group compared with the control group. Disease-free time for alopecia was longer in the combined compared with the control group. Overall, the side effects were significantly more serious in the control compared with the combined group. Patients in the combined group had better quality of life than the control patients.
Xiaoaiping can improve alopecia, nausea and vomiting, and diarrhea symptoms, WBC count, AST levels, and the quality of life in breast cancer patients.
探讨中药消癌平治疗乳腺癌患者化疗所致副作用的效果。
纳入2016年1月至2017年12月在我院就诊且符合入选标准的93例成年患者。患者被随机分为对照组（仅接受常规化疗）和联合组（接受常规化疗及消癌平）。收集人口统计学数据和临床变量，并评估包括脱发、恶心呕吐、腹泻、白细胞（WBC）计数、天冬氨酸转氨酶（AST）水平及生活质量等副作用。
两组间基本临床特征无差异。联合组3 - 4级脱发患者明显少于对照组，但1 - 2级脱发患者明显多于对照组。联合组脱发的无病时间长于对照组。总体而言，对照组的副作用明显比联合组严重。联合组患者的生活质量优于对照组患者。
消癌平可改善乳腺癌患者的脱发、恶心呕吐、腹泻症状、白细胞计数、AST水平及生活质量。
