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探索食用燕窝在减轻Wi-Fi对男性生殖健康影响方面的潜力。

Exploring edible bird nest's potential in mitigating Wi-Fi's impact on male reproductive health.

作者信息

Maluin Sofwatul Mokhtarah, Jaffar Farah Hanan Fathihah, Osman Khairul, Zulkefli Aini Farzana, Mat Ros Mohd Farisyam, Ibrahim Siti Fatimah

机构信息

Department of Physiology, Faculty of Medicine and Health Sciences Universiti Sains Islam Malaysia (USIM) Nilai Malaysia.

Department of Physiology, Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Malaysia.

出版信息

Reprod Med Biol. 2024 Sep 11;23(1):e12606. doi: 10.1002/rmb2.12606. eCollection 2024 Jan-Dec.

DOI:10.1002/rmb2.12606
PMID:39263384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11387989/
Abstract

PURPOSE

This study aimed to evaluate the protective effects of edible bird nest (EBN) against the detrimental impact of Wi-Fi on male reproductive health. Specifically, it examines whether EBN can mitigate Wi-Fi-induced changes in male reproductive hormones, estrogen receptors (ER), spermatogenesis, and sperm parameters.

METHODS

Thirty-six adult male rats were divided into six groups ( = 6): Control, Control EBN, Control E2, Wi-Fi, Wi-Fi+EBN, and Wi-Fi+E2. Control EBN and Wi-Fi+EBN groups received 250 mg/kg/day EBN, while Control E2 and Wi-Fi+E2 groups received 12 μg/kg/day E2 for 10 days. Wi-Fi exposure and EBN supplementation lasted eight weeks. Assessments included organ weight, hormone levels (FSH, LH, testosterone, and E2), ERα/ERβ mRNA and protein expression, spermatogenic markers (c-KIT and SCF), and sperm quality.

RESULTS

Wi-Fi exposure led to decreased FSH, testosterone, ERα mRNA, and sperm quality (concentration, motility, and viability). EBN supplementation restored serum FSH and testosterone levels, increased serum LH levels, and the testosterone/E2 ratio, and normalized mRNA ERα expression. Additionally, EBN increased sperm concentration in Wi-Fi-exposed rats without affecting motility or viability.

CONCLUSIONS

EBN plays a crucial role in regulating male reproductive hormones and spermatogenesis, leading to improved sperm concentration. This could notably benefit men experiencing oligospermia due to excessive Wi-Fi exposure.

摘要

目的

本研究旨在评估食用燕窝（EBN）对Wi-Fi对雄性生殖健康的有害影响的保护作用。具体而言，研究EBN是否能减轻Wi-Fi引起的雄性生殖激素、雌激素受体（ER）、精子发生及精子参数的变化。

方法

将36只成年雄性大鼠分为六组（每组n = 6）：对照组、对照EBN组、对照E2组、Wi-Fi组、Wi-Fi + EBN组和Wi-Fi + E2组。对照EBN组和Wi-Fi + EBN组每天接受250mg/kg的EBN，而对照E2组和Wi-Fi + E2组每天接受12μg/kg的E2，持续10天。Wi-Fi暴露和EBN补充持续8周。评估指标包括器官重量、激素水平（促卵泡生成素、促黄体生成素、睾酮和E2）、ERα/ERβ mRNA和蛋白表达、生精标志物（c-KIT和干细胞因子）以及精子质量。

结果

Wi-Fi暴露导致促卵泡生成素、睾酮、ERα mRNA及精子质量（浓度、活力和存活率）下降。补充EBN可恢复血清促卵泡生成素和睾酮水平，提高血清促黄体生成素水平及睾酮/E2比值，并使mRNA ERα表达正常化。此外，EBN可提高Wi-Fi暴露大鼠的精子浓度，而不影响其活力和存活率。

结论

EBN在调节雄性生殖激素和精子发生中起关键作用，可提高精子浓度。这对因过度暴露于Wi-Fi而患少精子症的男性可能具有显著益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/f44001fb7a74/RMB2-23-e12606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/fb29bb4ec968/RMB2-23-e12606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/34f13c6d21a6/RMB2-23-e12606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/8a7f12fe3709/RMB2-23-e12606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/1eda0b37fd39/RMB2-23-e12606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/f44001fb7a74/RMB2-23-e12606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/fb29bb4ec968/RMB2-23-e12606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/34f13c6d21a6/RMB2-23-e12606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/8a7f12fe3709/RMB2-23-e12606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/1eda0b37fd39/RMB2-23-e12606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59f1/11387989/f44001fb7a74/RMB2-23-e12606-g004.jpg

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