Tompkins L S
Clin Lab Med. 1985 Mar;5(1):99-107.
DNA molecules and monoclonal antibodies can now be employed in the clinical laboratory to detect microorganisms in clinical samples. DNA probes are produced by cloning specific gene sequences which then react with homologous target DNA in the sample by DNA hybridization. Monoclonal antibodies are also produced by selection, cloning, and tagging, much like DNA probes. Both methods appear to be highly sensitive, specific, and rapid in the detection of microorganisms.
DNA分子和单克隆抗体现在可用于临床实验室，以检测临床样本中的微生物。DNA探针是通过克隆特定基因序列产生的，然后通过DNA杂交与样本中的同源靶DNA发生反应。单克隆抗体也通过筛选、克隆和标记产生，很像DNA探针。这两种方法在检测微生物方面似乎都具有高度敏感性、特异性和快速性。
