Department of Medicine and Surgery, University of Parma, Parma, Italy.
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
J Neurol. 2024 Nov;271(11):7120-7140. doi: 10.1007/s00415-024-12674-w. Epub 2024 Sep 12.
Blood-based biomarkers (BBM) are becoming easily detectable tools to reveal pathological changes in Alzheimer's disease (AD). A comprehensive and up-to-date overview of the association between BBM and brain MRI parameters is not available. This systematic review aimed to summarize the literature on the associations between the main BBM and MRI markers across the clinical AD continuum. A systematic literature search was carried out on PubMed and Web of Science and a total of 33 articles were included. Hippocampal volume was positively correlated with Aβ42 and Aβ42/Aβ40 and negatively with Aβ40 plasma levels. P-tau181 and p-tau217 concentrations were negatively correlated with temporal grey matter volume and cortical thickness. NfL levels were negatively correlated with white matter microstructural integrity, whereas GFAP levels were positively correlated with myo-inositol values in the posterior cingulate cortex/precuneus. These findings highlight consistent associations between various BBM and brain MRI markers even in the pre-clinical and prodromal stages of AD. This suggests a possible advantage in combining multiple AD-related markers to improve accuracy of early diagnosis, prognosis, progression monitoring and treatment response.
基于血液的生物标志物 (BBM) 正成为揭示阿尔茨海默病 (AD) 病理变化的便捷检测工具。目前尚无关于 BBM 与脑 MRI 参数之间关联的全面、最新综述。本系统评价旨在总结主要 BBM 与 MRI 标志物在 AD 临床连续体中相关性的文献。在 PubMed 和 Web of Science 上进行了系统的文献检索，共纳入 33 篇文章。海马体积与 Aβ42 和 Aβ42/Aβ40 呈正相关，与 Aβ40 血浆水平呈负相关。p-tau181 和 p-tau217 浓度与颞叶灰质体积和皮质厚度呈负相关。NfL 水平与白质微观结构完整性呈负相关，而 GFAP 水平与后扣带回/楔前叶肌醇值呈正相关。这些发现强调了各种 BBM 与脑 MRI 标志物之间的一致关联，即使在 AD 的临床前和前驱期也是如此。这表明，联合使用多种 AD 相关标志物可能具有优势，有助于提高早期诊断、预后、进展监测和治疗反应的准确性。
