血浆 p-tau231 和 p-tau217 可反映认知障碍个体中 tau 缠结的聚集情况。
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.
机构信息
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Hospital Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Montréal, Québec, Canada.
出版信息
Alzheimers Dement. 2023 Oct;19(10):4463-4474. doi: 10.1002/alz.13393. Epub 2023 Aug 3.
INTRODUCTION
Phosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-β (Aβ) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify Aβ and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI).
METHODS
We assessed 138 CU and 87 CI with available plasma p-tau231, 217 , and 181, Aβ42/40, GFAP and Aβ- and tau-PET.
RESULTS
In CU, only plasma p-tau231 and p-tau217 significantly improved the performance of the demographics in detecting Aβ-PET positivity, while no plasma biomarker provided additional information to identify tau-PET positivity. In CI, p-tau217 and GFAP significantly contributed to demographics to identify both Aβ-PET and tau-PET positivity, while p-tau231 only provided additional information to identify tau-PET positivity.
DISCUSSION
Our results support plasma p-tau231 and p-tau217 as state markers of early Aβ deposition, but in later disease stages they inform on tau tangle accumulation.
HIGHLIGHTS
It is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex). Plasma p-tau231 and p-tau217 contribute to demographic information to identify brain Aβ pathology in preclinical AD. In CI individuals, plasma p-tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p-tau217 and GFAP inform on both Aβ deposition and tau pathology.
简介
磷酸化tau（p-tau）生物标志物最近被提出可以代表脑淀粉样β（Aβ）病理学。在这里，我们评估了血浆生物标志物的贡献，以超越人口统计学（年龄和性别）提供的信息，以识别认知未受损（CU）和受损（CI）个体中的 Aβ 和 tau 病理学。
方法
我们评估了 138 名 CU 和 87 名 CI，这些人有可用的血浆 p-tau231、217 和 181、Aβ42/40、GFAP 和 Aβ 和 tau-PET。
结果
在 CU 中，只有血浆 p-tau231 和 p-tau217 显著提高了人口统计学检测 Aβ-PET 阳性的性能，而没有血浆生物标志物提供额外的信息来识别 tau-PET 阳性。在 CI 中，p-tau217 和 GFAP 显著有助于人口统计学识别 Aβ-PET 和 tau-PET 阳性，而 p-tau231 仅提供额外的信息来识别 tau-PET 阳性。
讨论
我们的结果支持血浆 p-tau231 和 p-tau217 作为早期 Aβ 沉积的状态标志物，但在疾病的后期阶段，它们提供了 tau 缠结积累的信息。
重点
血浆生物标志物在 AD 谱中识别 AD 病理学的贡献有多少，除了人口统计学（年龄+性别）已经提供的信息，这仍然不清楚。血浆 p-tau231 和 p-tau217 有助于人口统计学信息识别临床前 AD 中的脑 Aβ 病理学。在 CI 个体中，血浆 p-tau231 有助于年龄和性别信息，以告知 tau 缠结的积累，而 p-tau217 和 GFAP 则告知 Aβ 沉积和 tau 病理学。
Zotero 插件