核糖体解体：从变异到影响的途径。

Ribosomes unraveled: The path from variant to impact.

机构信息

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

出版信息

Cell Genom. 2024 Sep 11;4(9):100658. doi: 10.1016/j.xgen.2024.100658.

DOI:10.1016/j.xgen.2024.100658

PMID:39265527

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11480852/

Abstract

In this issue of Cell Genomics, Rothschild et al. reveal how ribosomal RNA diversity impacts ribosome structure and its implications for health and disease. Their innovative methodologies uncover distinct ribosome subtypes with significant structural variations and expression patterns. This work reveals connections to tissue-specific biology and cancer, positing new research avenues.

摘要

在本期《细胞基因组学》中，Rothschild 等人揭示了核糖体 RNA 多样性如何影响核糖体结构及其对健康和疾病的影响。他们创新的方法学揭示了具有显著结构差异和表达模式的不同核糖体亚型。这项工作揭示了与组织特异性生物学和癌症的联系，提出了新的研究途径。