RNA在核糖体功能中的作用。

The involvement of RNA in ribosome function.

作者信息

Moore Peter B, Steitz Thomas A

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520-8107, USA.

出版信息

Nature. 2002 Jul 11;418(6894):229-35. doi: 10.1038/418229a.

DOI:10.1038/418229a

PMID:12110899

Abstract

The ribosome is a particle made of RNA and protein that is found in abundance in all cells that are actively making protein. It catalyses the messenger RNA-directed synthesis of proteins. Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution.

摘要

核糖体是一种由RNA和蛋白质组成的颗粒，在所有活跃合成蛋白质的细胞中大量存在。它催化以信使RNA为模板的蛋白质合成。最近的结构研究表明，核糖体的RNA组分在其功能的各个方面都有着深远的参与，这支持了蛋白质是在核糖体进化后期才添加到其中的假说。