Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Spain; Microfluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Spain; Microfluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
Anal Chim Acta. 2024 Oct 23;1327:342988. doi: 10.1016/j.aca.2024.342988. Epub 2024 Jul 19.
The great majority of published microfluidic wearable platforms for sweat sensing focus on the development of the technology to fabricate the device, the integration of sensing materials and actuators and the fluidics of sweat within the device. However, very few papers have discussed the physiological relevance of the metabolites measured using these novel approaches. In fact, some of the analytes present in sweat, which serve as biomarkers in blood, do not show a correlation with blood levels. This discrepancy can be attributed to factors such as contamination during measurements, the metabolism of sweat glands, or challenges in obtaining significant samples. The objective of this review is to present a critical and meaningful insight into the real applicability and potential use of wearable technology for improving health and sport performance. It also discusses the current limitations and future challenges of microfluidics, aiming to provide accurate information about the actual needs in this field. This work is expected to contribute to the future development of more suitable wearable microfluidic technology for health and sports science monitoring, using sweat as the biofluid for analysis.
大多数已发表的用于汗液检测的微流控可穿戴平台都专注于开发制造设备的技术、将传感材料和执行器集成到设备中以及设备内的汗液流体动力学。然而，很少有论文讨论使用这些新方法测量的代谢物的生理相关性。事实上，汗液中一些作为血液生物标志物的分析物与血液水平没有相关性。这种差异可能归因于测量过程中的污染、汗腺的新陈代谢，或获得有意义样本的挑战。本综述的目的是对可穿戴技术在改善健康和运动表现方面的实际适用性和潜在用途进行批判性和有意义的深入分析。它还讨论了微流控技术目前的局限性和未来的挑战，旨在提供该领域实际需求的准确信息。这项工作有望为使用汗液作为分析生物流体的健康和运动科学监测的更合适的可穿戴微流控技术的未来发展做出贡献。
