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表达神经生长因子的转导嗅鞘细胞移植后实验性阿尔茨海默病大鼠认知功能的研究

The Study of Cognitive Functions of Rats with Experimental Alzheimer's Disease after Transplantation of Transduced Olfactory Ensheathing Cells Expressing Nerve Growth Factor.

作者信息

Karsuntseva E K, Voronova A D, Shishkina V S, Pokidko V Yu, Mukhina A I, Chadin A V, Fursa G A, Fedorov A V, Stepanova O V, Chekhonin V P

机构信息

V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.

Lomonosov Moscow State University, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2025 May;179(1):127-134. doi: 10.1007/s10517-025-06446-3. Epub 2025 Jul 19.

DOI:10.1007/s10517-025-06446-3
PMID:40682644
Abstract

We evaluated the efficiency of transplantation of a gene-cell construct based on olfactory ensheathing cells expressing neurotrophic NGF in female Wistar rats with an experimental model of Alzheimer's disease. NGF improved long-term memory and learning ability in the passive avoidance test at week 3 after cell transplantation.

摘要

我们在患有阿尔茨海默病实验模型的雌性Wistar大鼠中，评估了基于表达神经营养因子NGF的嗅鞘细胞构建的基因-细胞复合物移植的效率。在细胞移植后第3周的被动回避试验中，NGF改善了长期记忆和学习能力。

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本文引用的文献

1
The Effect of Transplantation of Ensheathing Cells of the Olfactory Mucosa into the Hippocampal Area on the Restoration of Cognitive Abilities in Rats with Experimental Alzheimer's Disease.嗅黏膜成鞘细胞移植至海马区对实验性阿尔茨海默病大鼠认知能力恢复的影响
Bull Exp Biol Med. 2024 Nov;178(1):115-121. doi: 10.1007/s10517-024-06293-8. Epub 2024 Nov 23.
2
The Use of Neurotrophic Factors as a Promising Strategy for the Treatment of Neurodegenerative Diseases (Review).神经营养因子在神经退行性疾病治疗中的应用（综述）。
Bull Exp Biol Med. 2024 Aug;177(4):517-527. doi: 10.1007/s10517-024-06218-5. Epub 2024 Sep 12.
3
Transduced Olfactory Mucosa Cells Expressing Nerve Growth Factor for the Therapy of Experimental Spinal Cord Cysts.
转导嗅黏膜细胞表达神经生长因子治疗实验性脊髓囊肿。
Bull Exp Biol Med. 2024 Aug;177(4):552-558. doi: 10.1007/s10517-024-06222-9. Epub 2024 Sep 12.
4
Updates on mouse models of Alzheimer's disease.阿尔茨海默病小鼠模型的最新进展。
Mol Neurodegener. 2024 Mar 11;19(1):23. doi: 10.1186/s13024-024-00712-0.
5
Potential therapeutic effect of olfactory ensheathing cells in neurological diseases: neurodegenerative diseases and peripheral nerve injuries.嗅鞘细胞在神经疾病中的潜在治疗作用：神经退行性疾病和周围神经损伤。
Front Immunol. 2023 Oct 17;14:1280186. doi: 10.3389/fimmu.2023.1280186. eCollection 2023.
6
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease.神经生长因子受体（Ngfr）通过抑制阿尔茨海默病中反应性星形胶质细胞的Lcn2/Slc22a17信号传导来诱导神经源性可塑性。
NPJ Regen Med. 2023 Jul 10;8(1):33. doi: 10.1038/s41536-023-00311-5.
7
Application of Behavioral Tests for Evaluation of an Experimental Model of Alzheimer's Disease in Female Rats.应用行为测试评估雌性大鼠阿尔茨海默病实验模型。
Bull Exp Biol Med. 2023 May;175(1):126-131. doi: 10.1007/s10517-023-05823-0. Epub 2023 Jun 19.
8
Microglia and Alzheimer's Disease.小胶质细胞与阿尔茨海默病。
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