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气候变化与抗生素耐药性:范围综述。

Climate change and antibiotic resistance: A scoping review.

机构信息

Unit for Research in Emergency and Disaster, University of Oviedo, Oviedo, Spain.

出版信息

Environ Microbiol Rep. 2024 Oct;16(5):e70008. doi: 10.1111/1758-2229.70008.

Abstract

This scoping review aimed to investigate the potential association between climate change and the rise of antibiotic resistance while also exploring the elements of climate change that may be involved. A scoping review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews, comprehensively searching scientific literature up to 31 January 2024. Multiple databases were utilized, including MEDLINE, Web of Science and SCOPUS. Various search strategies were employed, and selection criteria were established to include articles relevant to antibiotic resistance and climate change. The review included 30 selected articles published predominantly after 2019. Findings from these studies collectively suggest that rising temperatures associated with climate change can contribute to the proliferation of antibiotic resistance, affecting diverse ecosystems. This phenomenon is observed in soil, glaciers, rivers and clinical settings. Rising temperatures are associated with a rise in the prevalence of antibiotic resistance across various environments, raising concerns for global health. However, these studies provide valuable insights but do not establish a definitive causal link between environmental temperature and antibiotic resistance. The selective pressure exerted by antibiotics and their residues in ecosystems further complicates the issue.

摘要

这篇范围综述旨在探讨气候变化与抗生素耐药性上升之间的潜在关联,并探索可能涉及的气候变化因素。根据系统评价和荟萃分析扩展的首选报告项目进行了范围综述,全面搜索了截至 2024 年 1 月 31 日的科学文献。使用了多个数据库,包括 MEDLINE、Web of Science 和 SCOPUS。采用了各种搜索策略,并制定了选择标准,以纳入与抗生素耐药性和气候变化相关的文章。综述包括 30 篇主要发表于 2019 年后的选定文章。这些研究的结果共同表明,与气候变化相关的气温上升可能导致抗生素耐药性的扩散,影响到各种生态系统。这种现象在土壤、冰川、河流和临床环境中都有观察到。在各种环境中,抗生素耐药性的流行率与气温上升相关,这引起了对全球健康的关注。然而,这些研究提供了有价值的见解,但并没有在环境温度与抗生素耐药性之间建立明确的因果关系。抗生素及其在生态系统中的残留施加的选择压力进一步使问题复杂化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42e0/11393301/a20a8fea6a44/EMI4-16-e70008-g001.jpg

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