Gan Yu, Wu Zhi-Hong, Li Qian-Long, Lu Zhao-Xia, Chen Lin-Lin
Department of Gastroenterolog, Xiangya Hospital, Central South University, Changsha 410008, China (Lu Z-X, Email: 3867903@163. com).
North Sichuan Medical College, Nanchong, Sichuan 637000, China(Chen L-L, Email: 35398784@qq. com).
Zhongguo Dang Dai Er Ke Za Zhi. 2024;26(9):995-1001. doi: 10.7499/j.issn.1008-8830.2405055.
infection (CDI) is a major cause of hospital-acquired gastrointestinal infections in children. Current treatment for pediatric CDI primarily involves antibiotics; however, some children experience recurrence after antibiotic treatment, and those with initial recurrence remain at risk for further recurrences following subsequent antibiotic therapy. In such cases, careful consideration of treatment options is necessary. Fecal microbiota transplantation has been shown to be effective for recurrent CDI and has a high safety profile. This article reviews the latest research on the pathogenesis, risk factors, diagnosis, and treatment of pediatric CDI domestically and internationally, with a particular focus on fecal microbiota transplantation therapy.
艰难梭菌感染(CDI)是儿童医院获得性胃肠道感染的主要原因。目前儿童CDI的治疗主要涉及抗生素;然而,一些儿童在抗生素治疗后会复发,且初次复发的儿童在后续抗生素治疗后仍有进一步复发的风险。在这种情况下,有必要仔细考虑治疗方案。粪便微生物群移植已被证明对复发性CDI有效且安全性高。本文综述了国内外关于儿童CDI的发病机制、危险因素、诊断和治疗的最新研究,特别关注粪便微生物群移植疗法。