Ding Qike, Lin Lihong, Li Xiaoting, Xie Xiaoping, Lu Tao
Department of Dermatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Front Med (Lausanne). 2024 Aug 29;11:1461596. doi: 10.3389/fmed.2024.1461596. eCollection 2024.
While several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and atopic dermatitis remains limited. Our cross-sectional study seeks to examine the association between SII and atopic dermatitis among outpatient US adults.
This compensatory cross-sectional study utilized NHANES data from 2001-2006 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of sub-groups.
Higher levels of SII were positively associated with an increased risk of atopic dermatitis in adults with BMI <30 (OR, 1.44; 95% CI, 1.10-1.90) ( = 0.010).
Our findings suggested SII higher than 330 × 10/L was positively associated with a high risk of atopic dermatitis in US adults with BMI <30. To our knowledge, this is the first study focused on the risk of higher SII on atopic dermatitis in the outpatient US population. Currently, there are differences in the standards used to diagnose atopic dermatitis across countries, and our study may have implications.
虽然多项研究指出较高的全身免疫炎症指数（SII）与多种疾病相关，但关于SII与特应性皮炎之间关联的研究仍然有限。我们的横断面研究旨在探讨美国门诊成年人群中SII与特应性皮炎之间的关联。
这项代偿性横断面研究利用了2001 - 2006年周期的美国国家健康与营养检查调查（NHANES）数据，进行样本加权多元逻辑回归和亚组分层分析。
在体重指数（BMI）<30的成年人中，较高水平的SII与特应性皮炎风险增加呈正相关（比值比[OR]，1.44；95%置信区间[CI]，1.10 - 1.90）（P = 0.010）。
我们的研究结果表明，在BMI<30的美国成年人中，SII高于330×10⁹/L与特应性皮炎高风险呈正相关。据我们所知，这是第一项关注美国门诊人群中较高SII对特应性皮炎风险影响的研究。目前，各国用于诊断特应性皮炎的标准存在差异，我们的研究可能具有一定意义。
