Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, Jiangsu, China.
BMC Public Health. 2023 Jul 24;23(1):1416. doi: 10.1186/s12889-023-16338-8.
BACKGROUND: Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass. METHODS: This study was a cross-sectional study based on National Health and Nutrition Examination Survey (2011-2018). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Appendicular skeletal muscle index was used to define low muscle mass. The individuals were divided into four groups by the quartile of SII (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting and subgroup analysis were used to investigate the relationship between SII and sarcopenia. Subgroup analysis were based on demographic and clinical variables. RESULTS: There were 10,367 individuals enrolled in our final analysis. The overall mean age was 39.39 years and 49.17% were males. The overall prevalence of low muscle mass in the study population was 8.77%. The smooth curve fitting analysis indicated a near-linear relationship between SII and low muscle mass. In multivariate weighted logistic regression analysis, the odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16-1.40) for low muscle mass when compared to lowest quartile of the SII. In subgroup analysis, SII still increased the risk of low muscle mass independently. CONCLUSION: The increased SII levels were associated with an increased risk of low muscle mass in a large population. Our study increased the understanding between inflammation and low muscle mass. Anti-inflammation therapy may be important for low muscle mass.
背景：慢性炎症反应与肌肉减少症有关，而全身免疫炎症指数（SII）是一种新的炎症指标。本研究旨在阐明 SII 与肌肉减少症之间的关系。
方法：本研究基于国家健康和营养检查调查（2011-2018 年）进行了一项横断面研究。SII 计算为血小板计数×中性粒细胞计数/淋巴细胞计数。四肢骨骼肌指数用于定义肌肉减少症。根据 SII 的四分位（Q1-Q4）将个体分为四组。采用多变量加权逻辑回归分析、平滑曲线拟合和亚组分析来探讨 SII 与肌少症之间的关系。亚组分析基于人口统计学和临床变量。
结果：最终纳入 10367 名个体进行分析。总体平均年龄为 39.39 岁，49.17%为男性。研究人群中肌肉减少症的总体患病率为 8.77%。平滑曲线拟合分析表明 SII 与肌肉减少症之间存在近似线性关系。在多变量加权逻辑回归分析中，与 SII 最低四分位数相比，Q4 发生肌肉减少症的比值比（OR）为 1.28（95%可信区间，1.16-1.40）。在亚组分析中，SII 仍独立增加肌肉减少症的风险。
结论：SII 水平升高与肌肉减少症的风险增加有关。本研究增加了对炎症与肌肉减少症之间关系的认识。抗炎治疗可能对肌肉减少症很重要。
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