Gorman S P, McCafferty D F, Woolfson A D, Anderson L
J Clin Hosp Pharm. 1985 Jun;10(2):185-92. doi: 10.1111/j.1365-2710.1985.tb01132.x.
The availability of a rapid and highly specific polarographic method of analysis for formaldehyde enabled investigation of the rate of formaldehyde release from noxythiolin solutions and actual concentrations of formaldehyde in solutions during clinical use and storage. The antimicrobial activity of noxythiolin solutions, equivalent pure formaldehyde solutions and N-methylthiourea individually or in combination was examined against standard bacteriological strains and clinical isolates. Several interesting observations were made. Clinical isolates were found to be relatively susceptible to noxythiolin in contrast to laboratory strains. The growth phase of the organism radically affects activity, early exponential phase cells being susceptible to 1.0% noxythiolin. Levels of formaldehyde detected in fresh noxythiolin solutions are extremely low and would not appear to be solely responsible for the antimicrobial activity observed.
一种用于甲醛的快速且高度特异性的极谱分析方法，使得研究在临床使用和储存期间，甲醛从诺西硫脲溶液中的释放速率以及溶液中甲醛的实际浓度成为可能。单独或联合检测了诺西硫脲溶液、等效纯甲醛溶液和N-甲基硫脲对标准菌株和临床分离株的抗菌活性。得出了一些有趣的观察结果。与实验室菌株相比，临床分离株对诺西硫脲相对敏感。生物体的生长阶段会从根本上影响活性，对数早期的细胞对1.0%的诺西硫脲敏感。新鲜诺西硫脲溶液中检测到的甲醛水平极低，似乎并非观察到的抗菌活性的唯一原因。
