Chattopadhyay B
Br Med J. 1977 Oct 29;2(6095):1121-2. doi: 10.1136/bmj.2.6095.1121.
Twelve strains of Pseudomonas aeruginosa, three strains of Klebsiella aerogenes, and two strains of Escherichia coli were found to be resistant to noxythiolin. Some of the pseudomonads were isolated from patients in the same ward, not all of whom were on noxythiolin treatment. The strains from these patients were indistinguishable from each other on phage typing, which suggested cross-contamination. No Gram-positive organism was found to be resistant to noxythiolin. Noxythiolin should not be used before a disc diffusion sensitivity test has been performed to determine whether the organisms are sensitive to it. This is particularly important when pseudomonads are the offending organisms.
发现12株铜绿假单胞菌、3株产气克雷伯菌和2株大肠杆菌对硝噻氧啉耐药。部分假单胞菌是从同一病房的患者中分离出来的，并非所有患者都接受了硝噻氧啉治疗。这些患者身上分离出的菌株在噬菌体分型上无法区分，这表明存在交叉污染。未发现革兰氏阳性菌对硝噻氧啉耐药。在进行纸片扩散药敏试验以确定微生物是否对硝噻氧啉敏感之前，不应使用硝噻氧啉。当假单胞菌为致病微生物时，这一点尤为重要。
