Asubiaro Joshua, Avajah Felix
Pharmaceutical Medicine, Accellacare, ICON plc, London, GBR.
Pharmaceutical Medicine, Bioluminux, Milton Keynes, GBR.
Cureus. 2024 Aug 12;16(8):e66734. doi: 10.7759/cureus.66734. eCollection 2024 Aug.
Platelet-rich plasma (PRP) has emerged as a promising treatment in aesthetic dermatology. This systematic review aims to evaluate the current evidence for PRP applications in skin rejuvenation, hair restoration, wound healing, and fat grafting. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across multiple databases and 13 studies meeting the inclusion criteria were selected for review. The Mixed Methods Appraisal Tool (MMAT) was used to assess the quality of included studies. The reviewed studies consistently reported positive outcomes for PRP across various applications. In skin rejuvenation, significant improvements in collagen density and overall skin appearance were observed. For hair restoration, studies showed mean increases of 18-27.7 hairs/cm² in treated areas. PRP demonstrated efficacy in accelerating wound healing across various wound types, including chronic ulcers. In fat grafting, PRP was associated with improved graft survival and integration. Patient satisfaction was generally high across all applications. However, there was significant heterogeneity in PRP preparation methods and treatment protocols among studies. This systematic review provides evidence supporting the efficacy of PRP in aesthetic dermatology, particularly in skin rejuvenation, hair restoration, wound healing, and fat grafting. PRP demonstrates a favorable safety profile across applications. However, the variability in study designs and PRP protocols highlights the need for standardization. Future research should focus on large-scale randomized controlled trials with standardized protocols and longer follow-up periods to solidify the evidence base for PRP in aesthetic dermatology.
富血小板血浆（PRP）已成为美容皮肤科一种很有前景的治疗方法。本系统评价旨在评估PRP在皮肤年轻化、毛发修复、伤口愈合和脂肪移植应用方面的现有证据。按照系统评价和Meta分析的首选报告项目（PRISMA）指南，在多个数据库中进行了全面的文献检索，并选择了13项符合纳入标准的研究进行综述。采用混合方法评估工具（MMAT）来评估纳入研究的质量。综述的研究一致报告了PRP在各种应用中的积极结果。在皮肤年轻化方面，观察到胶原蛋白密度和整体皮肤外观有显著改善。对于毛发修复，研究表明治疗区域平均每平方厘米增加18 - 27.7根头发。PRP在加速包括慢性溃疡在内的各种伤口类型的愈合方面显示出疗效。在脂肪移植中，PRP与改善移植物存活和整合有关。在所有应用中患者满意度普遍较高。然而，各研究之间PRP制备方法和治疗方案存在显著异质性。本系统评价提供了证据支持PRP在美容皮肤科的疗效，特别是在皮肤年轻化、毛发修复、伤口愈合和脂肪移植方面。PRP在各种应用中显示出良好的安全性。然而，研究设计和PRP方案的可变性突出了标准化的必要性。未来的研究应侧重于采用标准化方案和更长随访期的大规模随机对照试验，以巩固PRP在美容皮肤科的证据基础。
