New York, N.Y.
From the Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center.
Plast Reconstr Surg. 2018 May;141(5):1115-1123. doi: 10.1097/PRS.0000000000004279.
Despite the growing popularity of platelet-rich plasma, existing evidence supporting its efficacy remains controversial due to the lack of large-scale studies and standardized protocols for preparation and application. This article reviews its use in facial rejuvenation, fat grafting, acne scarring, and androgenic alopecia. Emphasis is placed on comparing methods of platelet-rich plasma preparation and application across studies.
A systematic review was performed for articles published between 2006 and 2015. All clinical studies and case reports that addressed platelet-rich plasma alone and/or in combination with fat grafting for facial rejuvenation, acne scarring, or androgenic alopecia were included.
Of the 22 articles included in the analysis, seven studies used platelet-rich plasma alone for facial rejuvenation, seven in combination with fat grafting, two for treatment of acne scarring, and six for treatment of androgenic alopecia. Individual study procedures, means of evaluation, and significant results are summarized. Although the majority of studies in this review report positive results, significant variation exists in preparation protocols and in the number and frequency of clinical treatments.
The majority of studies report positive results for all indications evaluated in this review, but the procedure is limited by the lack of a standardized method for preparation and application of platelet-rich plasma. The extent to which significant variability in platelet-rich plasma preparation and/or application methods may affect clinical outcomes is not completely clear. In the interim, we present a consolidation of platelet-rich plasma treatment techniques and outcomes currently in use to help guide physicians in their clinical practice.
尽管富血小板血浆的应用日益普及，但由于缺乏大规模研究和标准化的制备及应用方案，其疗效仍存在争议。本文综述了富血小板血浆在面部年轻化、脂肪移植、痤疮瘢痕和雄激素性脱发中的应用。重点比较了不同研究中富血小板血浆的制备和应用方法。
对 2006 年至 2015 年发表的文章进行了系统评价。纳入了所有单独或联合应用富血小板血浆治疗面部年轻化、痤疮瘢痕或雄激素性脱发的临床研究和病例报告。
在纳入分析的 22 篇文章中，有 7 篇研究单独应用富血小板血浆治疗面部年轻化，7 篇联合脂肪移植，2 篇治疗痤疮瘢痕，6 篇治疗雄激素性脱发。总结了各个研究的具体操作流程、评估方法和显著结果。虽然本综述中的大多数研究报告了所有评估适应证的阳性结果，但由于缺乏标准化的富血小板血浆制备和应用方法，该操作受到限制。富血小板血浆制备和/或应用方法的显著差异在多大程度上可能影响临床结果尚不完全清楚。在此期间，我们总结了目前正在使用的富血小板血浆治疗技术和结果，以帮助指导医生的临床实践。
