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奥曲肽治疗恶性小肠梗阻持续性胃肠液丢失的临床益处:病例报告及文献综述

Clinical Benefits of Octreotide for Managing Persistent Gastrointestinal Fluid Loss in Malignant Small Bowel Obstruction: A Case Report and Literature Review.

作者信息

Wannaphut Chalothorn, Kozai Landon A, Kulthamrongsri Narathorn, Kookanok Chutawat, Noree Wanprapit, Rodsom Kamonluk, Tantisattamo Ekamol, Acoba Jared

机构信息

Department of Internal Medicine, University of Hawai'i John A. Burns School of Medicine, Honolulu, USA.

Department of Medicine, American Heart Association Comprehensive Hypertension Center, University of California Irvine Medical Center, Orange, USA.

出版信息

Cureus. 2024 Aug 13;16(8):e66785. doi: 10.7759/cureus.66785. eCollection 2024 Aug.

DOI:10.7759/cureus.66785
PMID:39268309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11392515/
Abstract

Malignant small bowel obstruction (mSBO) is a frequent complication in patients with gastrointestinal or gynecologic cancers. For those with inoperable cancers and persistent obstructive symptoms, symptom palliation with a percutaneous gastrostomy tube (PGT) may be required. However, excessive fluid loss from the PGT can lead to significant fluid, electrolyte, and acid-base imbalances. We present a case of a man with metastatic colonic adenocarcinoma who developed mSBO, acute kidney injury, and metabolic alkalosis, all of which were effectively managed with octreotide.

摘要

恶性小肠梗阻(mSBO)是胃肠道或妇科癌症患者常见的并发症。对于那些患有无法手术切除的癌症且存在持续性梗阻症状的患者,可能需要通过经皮胃造瘘管(PGT)来缓解症状。然而,PGT导致的过多液体流失可引起严重的液体、电解质和酸碱失衡。我们报告一例患有转移性结肠腺癌的男性患者,该患者发生了mSBO、急性肾损伤和代谢性碱中毒,所有这些情况均通过奥曲肽得到有效控制。

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1
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本文引用的文献

1
Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.代谢性碱中毒的发病机制、诊断与治疗:2022 年核心课程。
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Management of intestinal obstruction in advanced malignancy.晚期恶性肿瘤肠梗阻的管理
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Crofelemer for the treatment of secretory diarrhea.可洛派韦用于治疗分泌性腹泻。
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Can malignant bowel obstruction in advanced cancer patients be treated at home?晚期癌症患者的恶性肠梗阻能否在家中治疗?
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Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans.α₂-肾上腺素能激动剂对人体胃肠道转运、结肠动力和感觉的影响。
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Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose.因摄入小苏打导致的严重代谢性碱中毒:两例未被怀疑为抗酸剂过量的患者病例报告
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