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基于聚脯氨酸的星型多肽热响应水凝胶的数字光处理

Digital Light Processing of Thermoresponsive Hydrogels from Polyproline-Based Star Polypeptides.

作者信息

Murphy Robert D, Cosgrave Muireann, Judge Nicola, Tinajero-Diaz Ernesto, Portale Giuseppe, Wu Bing, Heise Andreas

机构信息

Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.

Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, Groningen, 9747 AG, The Netherlands.

出版信息

Small. 2024 Dec;20(49):e2405578. doi: 10.1002/smll.202405578. Epub 2024 Sep 13.

DOI:10.1002/smll.202405578
PMID:39268774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11618715/
Abstract

The first report of star poly(L-proline) crosslinkers is disclosed for digital light processing 3D printing of thermoresponsive hydrogels. Through chain end functionalization of star poly(L-proline)s with methacryloyl groups, access to high-resolution defined 3D hydrogel structures via digital light processing is achieved through photoinitiated free radical polymerization. Changing the poly(L-proline) molecular weight has a direct influence on both thermoresponsiveness and printability, while shape-morphing behavior can be induced thermally.

摘要

首次报道了用于热响应水凝胶数字光处理3D打印的星形聚（L-脯氨酸）交联剂。通过用甲基丙烯酰基对星形聚（L-脯氨酸）进行链端功能化，通过光引发自由基聚合实现了通过数字光处理获得高分辨率的定义3D水凝胶结构。改变聚（L-脯氨酸）的分子量对热响应性和可打印性都有直接影响，而形状变形行为可以通过热诱导产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/0398d87579c9/SMLL-20-2405578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/3df8d8aa63e7/SMLL-20-2405578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/8b74956375d1/SMLL-20-2405578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/2b94e808e96b/SMLL-20-2405578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/0398d87579c9/SMLL-20-2405578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/3df8d8aa63e7/SMLL-20-2405578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/8b74956375d1/SMLL-20-2405578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/2b94e808e96b/SMLL-20-2405578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9be/11618715/0398d87579c9/SMLL-20-2405578-g005.jpg

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本文引用的文献

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Poly(l-proline)-Stabilized Polypeptide Nanostructures via Ring-Opening Polymerization-Induced Self-Assembly (ROPISA).通过开环聚合诱导自组装（ROPISA）制备聚（L-脯氨酸）稳定的多肽纳米结构。
ACS Macro Lett. 2024 Aug 20;13(8):1031-1036. doi: 10.1021/acsmacrolett.4c00400. Epub 2024 Jul 29.
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Ink Material Selection and Optical Design Considerations in DLP 3D Printing.DLP 3D打印中的墨水材料选择与光学设计考量
Appl Mater Today. 2023 Feb;30. doi: 10.1016/j.apmt.2022.101721. Epub 2022 Dec 20.
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Tailoring Writability and Performance of Star Block Copolypeptides Hydrogels through Side-Chain Design.
通过侧链设计定制星型嵌段共聚多肽水凝胶的可书写性和性能
Small. 2023 Dec;19(50):e2302794. doi: 10.1002/smll.202302794. Epub 2023 Jul 10.
4
High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding.高分子量聚脯氨酸作为一种潜在的生物源冰生长抑制剂：合成、冰重结晶抑制和特定冰面结合。
Biomacromolecules. 2023 Jun 12;24(6):2459-2468. doi: 10.1021/acs.biomac.2c01487. Epub 2023 Feb 21.
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Tailored Polypeptide Star Copolymers for 3D Printing of Bacterial Composites Via Direct Ink Writing.用于通过直接墨水书写对细菌复合材料进行3D打印的定制多肽星形共聚物。
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Memory Effect in Thermoresponsive Proline-based Polymers.温敏型脯氨酸基聚合物的记忆效应。
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Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline -carboxyanhydride.水辅助及蛋白质引发的脯氨酸羧酐快速可控开环聚合反应
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Deciphering the Backbone Noncovalent Interactions that Stabilize Polyproline II Conformation and Reduce cis Proline Abundance in Polyproline Tracts.解析稳定聚脯氨酸 II 构象和降低聚脯氨酸链中顺式脯氨酸丰度的骨架非共价相互作用。
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