基于聚脯氨酸的星型多肽热响应水凝胶的数字光处理

Murphy Robert D, Cosgrave Muireann, Judge Nicola, Tinajero-Diaz Ernesto, Portale Giuseppe, Wu Bing, Heise Andreas

Department of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.

Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, Groningen, 9747 AG, The Netherlands.

Small. 2024 Dec;20(49):e2405578. doi: 10.1002/smll.202405578. Epub 2024 Sep 13.

The first report of star poly(L-proline) crosslinkers is disclosed for digital light processing 3D printing of thermoresponsive hydrogels. Through chain end functionalization of star poly(L-proline)s with methacryloyl groups, access to high-resolution defined 3D hydrogel structures via digital light processing is achieved through photoinitiated free radical polymerization. Changing the poly(L-proline) molecular weight has a direct influence on both thermoresponsiveness and printability, while shape-morphing behavior can be induced thermally.

首次报道了用于热响应水凝胶数字光处理3D打印的星形聚（L-脯氨酸）交联剂。通过用甲基丙烯酰基对星形聚（L-脯氨酸）进行链端功能化，通过光引发自由基聚合实现了通过数字光处理获得高分辨率的定义3D水凝胶结构。改变聚（L-脯氨酸）的分子量对热响应性和可打印性都有直接影响，而形状变形行为可以通过热诱导产生。