BEI Resources, Manassas, Virginia, USA.
ATCC, Manassas, Virginia, USA.
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0118923. doi: 10.1128/aac.01189-23. Epub 2024 Sep 13.
BEI Resources, a National Institute of Allergy and Infectious Diseases-funded program managed by the American Type Culture Collection, serves researchers worldwide through the provision of a centralized repository for the acquisition, production, characterization, preservation, storage, and distribution of standardized biological resources targeting National Institutes of Health priority pathogens including bacteria, viruses, pathogenic fungi, and parasitic protozoa. These reference materials are critical for the development of diagnostics, vaccines, and therapeutics and are available to qualified registered investigators and institutions worldwide. Bioresources within BEI include well-characterized malaria isolates as part of the Malaria Research and Reference Reagent Resource Center (MR4). These isolates are critical for screening antimalarial compounds, conducting drug resistance studies, and for resistance surveillance and management. In our efforts to enhance the characterization of MR4 isolates, we measured antimalarial susceptibility of >100 isolates against a panel of standard antimalarial compounds. Our results provide valuable information to assist current and prospective users of the BEI Resources repository in making data-driven requests of isolates to meet their research needs.
BEI Resources 是一个由美国典型培养物保藏中心管理的、由美国国家过敏和传染病研究所资助的项目，通过为获取、生产、特性描述、保存、储存和分发针对美国国立卫生研究院优先病原体（包括细菌、病毒、致病性真菌和寄生原生动物）的标准化生物资源，为全球研究人员提供服务。这些参考材料对于诊断、疫苗和治疗药物的开发至关重要，并且可供全球合格的注册研究人员和机构使用。BEI 中的生物资源包括作为疟疾研究和参考试剂资源中心 (MR4) 的一部分的经过充分特征描述的疟疾分离株。这些分离株对于筛选抗疟化合物、进行耐药性研究以及耐药性监测和管理至关重要。在我们努力增强 MR4 分离株特征描述的过程中，我们测量了 >100 个分离株对一系列标准抗疟化合物的抗药性。我们的结果提供了有价值的信息，以帮助当前和潜在的 BEI 资源库用户根据他们的研究需求，针对分离株提出数据驱动的请求。
