Department of Molecular and Cell Biology, Faculty of Science, University of Mazandaran, Babolsar, 47416-95447, Mazandaran, Iran.
Mol Biol Rep. 2024 Sep 13;51(1):980. doi: 10.1007/s11033-024-09919-2.
Superoxide dismutase 3 (SOD3) is a type of antioxidant enzyme, which plays an important role in converting superoxide anion into hydrogen peroxide through its extracellular activity. This enzyme has been widely studied and evaluated from various points of view, including maintaining cellular redox balance, protecting against oxidative damage, and enhancing overall cellular resilience. The current paper focuses on SOD3 expression from a functional perspective. In addition to a detailed examination of the gene and protein structure, we found ample evidence indicating that the expression level of SOD3 undergoes alterations in response to various transcription factors, signaling pathways, and diverse conditions. These fluctuations, by disrupting the homeostasis of SOD3, can serve as crucial indicators of the onset or exacerbation of specific diseases. In this regard, significant efforts have been dedicated in recent years to the treatment of diseases through the regulation of SOD3 expression. The ultimate goal of this review is to extensively highlight and demonstrate the immense potential of SOD3 as a therapeutic target, emphasizing its profound impact on health outcomes.
超氧化物歧化酶 3（SOD3）是一种抗氧化酶，通过其细胞外活性在将超氧阴离子转化为过氧化氢方面发挥重要作用。该酶已从多个角度进行了广泛研究和评估，包括维持细胞氧化还原平衡、防止氧化损伤和增强整体细胞弹性。本文主要从功能角度关注 SOD3 的表达。除了对基因和蛋白质结构进行详细检查外，我们还发现了大量证据表明，SOD3 的表达水平会根据各种转录因子、信号通路和不同条件发生变化。这些波动通过破坏 SOD3 的体内平衡，可以作为特定疾病发生或恶化的关键指标。在这方面，近年来，人们为通过调节 SOD3 的表达来治疗疾病做出了巨大努力。本综述的最终目标是广泛强调和展示 SOD3 作为治疗靶点的巨大潜力，强调其对健康结果的深远影响。
