Yen J T, Nienaber J A, Pond W G, Varel V H
J Nutr. 1985 Aug;115(8):970-9. doi: 10.1093/jn/115.8.970.
Five experiments were done with 34 weanling and 24 growing crossbred gilts. Individually penned pigs were fed ad libitum (expt 1) or pair-fed (expt 2 through expt 5) for either 2 (expt 1 through expt 4) or 3 (expt 5) wk. Mean body weight gain and gain/feed values were significantly (P less than 0.05) greater in pigs fed carbadox (a synthetic antimicrobial). Fasting O2 consumption and CO2 production of pigs were measured during the 32- to 48-h (expt 1, 4 and 5) or during the 24- to 40-h (expt 2 and 3) postprandial periods with indirect open circuit calorimeters. Carbadox reduced O2 consumption significantly (P less than 0.05) in expt 2, but had no significant effect on CO2 production in any of the five experiments. The weight of thyroid gland and the plasma concentrations of L-3,3',5-triiodothyronine (T3) and thyroxine (T4) of pigs were not altered by carbadox. The mean weight, but not the length, of small intestine tended to be less in pigs fed carbadox. It is suggested that the growth-promoting effect of carbadox on young pigs may be associated with the weight of small intestine and its physiological processes such as metabolic rate. However, no definite effects of carbadox on whole-animal fasting metabolic rate and thyroid function could be demonstrated by the methods used in the present study.
对34头断奶仔猪和24头生长中的杂交母猪进行了五项实验。将猪单独饲养在栏中，随意采食（实验1）或配对饲养（实验2至实验5），为期2周（实验1至实验4）或3周（实验5）。饲喂卡巴氧（一种合成抗菌剂）的猪的平均体重增加和增重/饲料值显著更高（P < 0.05）。在餐后32至48小时（实验1、4和5）或24至40小时（实验2和3）期间，使用间接开路热量计测量猪的空腹氧气消耗量和二氧化碳产生量。在实验2中，卡巴氧显著降低了氧气消耗量（P < 0.05），但在五项实验中的任何一项中对二氧化碳产生量均无显著影响。卡巴氧对猪的甲状腺重量以及血浆中L-3,3',5-三碘甲状腺原氨酸（T3）和甲状腺素（T4）的浓度没有改变。饲喂卡巴氧的猪的小肠平均重量有降低趋势，但长度没有变化。提示卡巴氧对幼猪的促生长作用可能与小肠重量及其代谢率等生理过程有关。然而，本研究中使用的方法未能证明卡巴氧对全动物空腹代谢率和甲状腺功能有明确影响。
