Department of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Cell Rep. 2024 Sep 24;43(9):114732. doi: 10.1016/j.celrep.2024.114732. Epub 2024 Sep 12.
An interconnected group of cortical regions distributed across the primate inferotemporal cortex forms a network critical for face perception. Understanding the microarchitecture of this face network can refine mechanistic accounts of how individual areas function and interact to support visual perception. To address this, we acquire a unique dataset in macaque monkeys combining fMRI to localize face patches in vivo and then ex vivo histology to resolve their histo-architecture across cortical depths in the same individuals. Our findings reveal that face patches differ based on cytochrome oxidase (CO) and, to a lesser extent, myelin staining, with the middle lateral (ML) face patch exhibiting pronounced CO staining. Histo-architectonic differences are less pronounced when using probabilistic definitions of face patches, underscoring the importance of precision mapping integrating in vivo and ex vivo measurements in the same individuals. This study indicates that the macaque face patch network is composed of architectonically distinct components.
一组相互连接的皮质区域分布在灵长类动物的下颞叶皮质中，形成了一个对面孔感知至关重要的网络。了解这个面孔网络的微观结构可以细化关于个体区域如何发挥作用以及相互作用以支持视觉感知的机制解释。为了解决这个问题，我们在猕猴中获取了一个独特的数据集，结合 fMRI 在体内定位面孔斑块，然后在体外组织学中在同一个体的皮质深度范围内解析它们的组织架构。我们的研究结果表明，面孔斑块基于细胞色素氧化酶（CO）存在差异，并且在较小程度上基于髓鞘染色存在差异，其中中间外侧（ML）面孔斑块表现出明显的 CO 染色。当使用面孔斑块的概率定义时，组织学差异不太明显，这强调了在同一个体中整合体内和体外测量的精确映射的重要性。这项研究表明，猕猴面孔斑块网络由具有不同结构的成分组成。
