Shang Wenjuan, Xin Hui, Hou Xiandeng, Wu Li, Wu Lan
Analytical & Testing Center, Sichuan University, Chengdu, Sichuan 610064, China.
College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
ACS Appl Mater Interfaces. 2024 Sep 25;16(38):51679-51689. doi: 10.1021/acsami.4c10473. Epub 2024 Sep 13.
In this work, a boric-acid-modified FeO@Au@BA-MOF composite material as a multifunctional SERS substrate was ingeniously constructed for detecting both pathogens and antibiotics as well as photothermally inactivating the pathogens. Through improving the dispersity and stability of gold nanoparticles (Au NPs), leveraging the specificity of boric acid (BA) groups in recognizing cis-diol structures, and the ability of SERS technology to provide unique fingerprint spectra of targets, the sensitive and stable detection of pathogens and antibiotics was achieved. Compared with Au NPs and FeO@Au, the SERS enhancement factor of FeO@Au@BA-MOF was 4.31 × 10, which was about 400 times and 16 times higher than the former two, respectively. Among the existing work, the limit of detection for pathogens was lower or comparable, and it exhibited good stability, maintaining consistent performance for 23 days. Additionally, this substrate achieved efficient photothermal inactivation of pathogens under both near-infrared light and natural light excitation. Within 8 min of near-infrared light irradiation, the bactericidal rates for and reach 100% and 99.3%, respectively.
在这项工作中，一种硼酸修饰的FeO@Au@BA-MOF复合材料被巧妙地构建为多功能表面增强拉曼光谱（SERS）基底，用于检测病原体和抗生素，并对病原体进行光热灭活。通过提高金纳米颗粒（Au NPs）的分散性和稳定性，利用硼酸（BA）基团识别顺式二醇结构的特异性，以及SERS技术提供目标独特指纹光谱的能力，实现了对病原体和抗生素的灵敏且稳定的检测。与Au NPs和FeO@Au相比，FeO@Au@BA-MOF的SERS增强因子为4.31×10，分别比前两者高约400倍和16倍。在现有工作中，病原体的检测限较低或与之相当，并且它表现出良好的稳定性，在23天内性能保持一致。此外，该基底在近红外光和自然光激发下均实现了对病原体的高效光热灭活。在近红外光照射8分钟内，大肠杆菌和金黄色葡萄球菌的杀菌率分别达到100%和99.3%。
