Amity Institute of Biotechnology, Amity University, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra, India, 410206; Centre for Computational Biology and Translational Research, Amity Institute of Biotechnology, Amity University, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra, India, 410206.
Amity Institute of Biotechnology, Amity University, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra, India, 410206.
Carbohydr Res. 2024 Nov;545:109271. doi: 10.1016/j.carres.2024.109271. Epub 2024 Sep 7.
Breast cancer presents a significant global health challenge, driving the development of novel treatment strategies for therapeutic interventions. Nanotechnology has emerged as a promising avenue for addressing this challenge, with Chitosan (CS) nanoparticles receiving prominence due to their unique characteristics and multitude of potential applications. This review provides a comprehensive overview of the role of Chitosan nanoparticles in breast cancer therapy. The review begins by emphasizing the prevalence and importance of breast cancer as a major health issue, underscoring the necessity for effective treatments. It then delves into the application of Chitosan nanoparticles in breast cancer therapy. One key aspect discussed is their role as carriers for anticancer drugs, enabling targeted delivery and improved cellular uptake. Furthermore, the review explores modified Chitosan nanoparticles and strategies for enhancing their efficacy and specificity in breast cancer treatment. It also examines Chitosan conjugates and hybrids, which offer innovative approaches for combination therapy. Additionally, metal and magnetic Chitosan nanoparticles are discussed spanning their capacity to assist in imaging, hyperthermia, as well as targeted drug delivery. In conclusion, the review summarizes the current research landscape regarding Chitosan nanoparticles for breast cancer therapy and offers insights into future directions. Overall, the review highlights the versatility, potential benefits, and future prospects of Chitosan nanoparticles in combating breast cancer.
乳腺癌是一项重大的全球健康挑战，促使人们开发新的治疗策略进行治疗干预。纳米技术已成为应对这一挑战的一种有前途的途径，壳聚糖（CS）纳米粒子因其独特的特性和众多潜在的应用而备受关注。本综述全面概述了壳聚糖纳米粒子在乳腺癌治疗中的作用。综述首先强调了乳腺癌作为主要健康问题的普遍性和重要性，突出了有效治疗的必要性。然后，综述探讨了壳聚糖纳米粒子在乳腺癌治疗中的应用。讨论的一个关键方面是它们作为抗癌药物载体的作用，能够实现靶向递送和提高细胞摄取。此外，还探讨了修饰的壳聚糖纳米粒子和提高其在乳腺癌治疗中疗效和特异性的策略。综述还研究了壳聚糖缀合物和杂化材料，它们提供了联合治疗的创新方法。此外，还讨论了金属和磁性壳聚糖纳米粒子，它们能够辅助成像、热疗以及靶向药物递送。总之，综述总结了当前关于壳聚糖纳米粒子治疗乳腺癌的研究现状，并对未来的发展方向提出了见解。总的来说，综述强调了壳聚糖纳米粒子在治疗乳腺癌方面的多功能性、潜在优势和未来前景。
