Department of Translational Immunology and Experimental Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland.
Pharmacol Res. 2024 Oct;208:107411. doi: 10.1016/j.phrs.2024.107411. Epub 2024 Sep 11.
Despite considerable improvements in understanding the biology of glioblastoma (GB), it still remains the most lethal type of brain tumor in adults. The role of innate immune cells in the development of GB was recently described. In particular, the tumor-immune cell interactions are thought to be critical in enabling tumor tolerance and even protection against therapeutics. Interestingly, the GB cells express proteins belonging to the family of intracellular pattern-recognition receptors, namely the NOD-like receptors (NLRs). Their activation may trigger the formation of the inflammasome complex leading to the secretion of mature IL-1β and IL-18 and thus resulting in cell death. Intrudingly, the expression of most NLRs was found to be correlated with tumor progression and poor prognosis. We speculate that recognizing the role of NOD-like receptors in GB has the potential to improve the effectiveness of diagnostic tools and prognosis, while also encouraging the development of novel precision medicine-based therapies.
尽管人们对胶质母细胞瘤 (GB) 的生物学特性有了相当大的了解，但它仍然是成年人中最致命的脑肿瘤类型。最近描述了固有免疫细胞在 GB 发展中的作用。特别是，肿瘤-免疫细胞相互作用被认为是使肿瘤耐受甚至对治疗具有保护作用的关键。有趣的是，GB 细胞表达属于细胞内模式识别受体家族的蛋白质，即 NOD 样受体 (NLRs)。它们的激活可能会触发炎性小体复合物的形成，导致成熟的 IL-1β 和 IL-18 的分泌，从而导致细胞死亡。值得注意的是，大多数 NLR 的表达与肿瘤进展和预后不良相关。我们推测，认识到 NOD 样受体在 GB 中的作用有可能提高诊断工具和预后的有效性，同时鼓励开发基于新型精准医学的疗法。
